Hi cholesterol and rectal cancer

Actions and Decisions
Concise Consultations for the Clinical Pathologist.
ASCP press 1983

Cardiac Risk Assessment .............

There is a positive correlation between hypercholesterolemia and cancer of
the rectum (relative risk in men (P<0.05) 1.65, with TC levels >7.15 mmol/l
(275 mg/dl)

Follow-up recommendations for the patient

Check for stool occult blood loss and consider recommending colonoscopy if
TC > 7.15 (275 mg/dl) in a male.

Tomberg SA; Risk of cancer of the colon and rectum in relation to serum
cholesterol and beta-lipoprotein. N Engl J Med 1986; 315:1629-1633



J Korean Med Sci. 2000 Dec;15(6):690-5. Related Articles, Books, LinkOut

Association of serum lipids and glucose with the risk of colorectal
adenomatous polyp in men: a case-control study in Korea.

Park SK, Joo JS, Kim DH, Kim YE, Kang D, Yoo KY.

Department of Preventive Medicine, Dongguk University College of Medicine,
Kyungju, Korea.

Previous studies on life style for colorectal cancer risk suggest that serum
lipids and glucose might be related to adenomatous polyps as well as to
colorectal carcinogenesis. This case-control study was conducted to
investigate the associations between serum lipids, blood glucose, and other
factors and the risk of colorectal adenomatous polyp. Male cases with
colorectal adenomatous polyp, histologically confirmed by colonoscopy
(n=134), and the same number of male controls matched by age for men were
selected in hospitals in Seoul, Korea between January 1997 and October 1998.
Serum lipids and glucose levels were tested after the subjects had fasted
for at least 12 hr. Conditional logistic regression showed that there was a
significant trend of increasing adenomatous polyp risk with the rise in
serum cholesterol level (Ptrend=0.07). Increasing trend for the risk with
triglyceride was also seen (Ptrend=0.01). HDL-cholesterol and
LDL-cholesterol had increasing trends for the risk, which were not
significant. In particular, it was noted that higher fasting blood glucose
level reduced the adenomatous polyp risk for men (Ptrend=0.001). This study
concluded that both serum cholesterol and triglyceride were positively
related to the increased risk for colorectal adenomatous polyp in Korea.
Findings on an inverse relationship between serum glucose and the risk
should be pursued in further studies.

PMID: 11194196 [PubMed - indexed for MEDLINE]




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