Re: LDL too low...?

Juhana Harju wrote:
: Juhana Harju wrote:
:: Juhana Harju wrote:
::: Jim Chinnis wrote:
:::
:::: I am not aware, however, of any evidence that lowering LDL to very
:::: low levels does anything except good. That's not saying that the
:::: lower the LDL the better, just that no one has shown otherwise at
:::: this point in time.
:::
::: LDL is definitely in association with total cholesterol. Very low
::: total cholesterol is associated with increased risk of
::: non-cardiovascular causes of death i.e. increased cancer risk and
::: increased risk of strokes.
::
:: Correction: I meant to say that besides cancer _hemorrhagic_ stroke
:: is associated with low cholesterol (not ischemic stroke which
:: accounts 80 % of strokes).
::
::: I recall seeing a recent study which
::: implicated that low total cholesterol was not only a result of being
::: ill already but a risk in itself. Still I can not provide any
::: reference as I can't remember which study it was.
:
: This is quite interesting:
:
: J Womens Health (Larchmt). 2004 Jan-Feb;13(1):41-53.
:
: Why Eve is not Adam: prospective follow-up in 149650 women and men of
: cholesterol and other risk factors related to cardiovascular and
: all-cause mortality.
:
: Ulmer H, Kelleher C, Diem G, Concin H.
:
: Institute of Biostatistics and Documentation, Leopold Franzens
: University of Innsbruck, Innsbruck, Austria.
:
: PURPOSE: To assess the impact of sex-specific patterns in cholesterol
: levels on all-cause and cardiovascular mortality in the Vorarlberg
: Health Monitoring and Promotion Programme (VHM&PP). METHODS : In this
: study, 67413 men and 82237 women (aged 20-95 years) underwent 454448
: standardized examinations, which included measures of blood pressure,
: height, weight, and fasting samples for cholesterol, triglycerides,
: gamma-glutamyl transferase (GGT), and glucose in the 15-year period
: 1985-1999. Relations between these variables and risk of death were
: analyzed using two approaches of multivariate analyses (Cox
: proportional hazard and GEE models). RESULTS: Patterns of cholesterol
: levels showed marked differences between men and women in relation to
: age and cause of death. The role of high cholesterol in predicting
: death from coronary heart disease could be confirmed in men of all
: ages and in women under the age of 50. In men, across the entire age
: range, although of borderline significance under the age of 50, and
: in women from the age of 50 onward only, low cholesterol was
: significantly associated with all-cause mortality, showing
: significant associations with death through cancer, liver diseases,
: and mental diseases. Triglycerides > 200 mg/dl had an effect in women
: 65 years and older but not in men. CONCLUSIONS: This large-scale
: population-based study clearly demonstrates the contrasting patterns
: of cholesterol level in relation to risk, particularly among those
: less well studied previously, that is, women of all ages and younger
: people of both sexes. For the first time, we demonstrate that the low
: cholesterol effect occurs even among younger respondents,
: contradicting the previous assessments among cohorts of older people
: that this is a proxy or marker for frailty occurring with age. PMID:
: 15006277
:
:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15006277&dopt=Citation

I found the full study:

http://www.maxima.or.at/kms/uploads/eve_not_adam_journal_fassung.pdf

::: On the other hand there are doctors (Ornish, Esselstyn) who have
::: succeeded in reversing atherosclerosis with a strict vegetarian or
::: almost vegetarian diet with the aim of reducing total and LDL
::: cholesterol as low as possible. T. Colin Campbell with his China
::: study is among those who promote a vegatarian (vegan) diet and a
::: very low cholesterol achieved mainly by diet.

--
Juhana


.

Relevant Pages

  • Re: How Statins cause cancer: Cholesterol is essential for cell signaling and deactivating ERK
    ... > death through cancer, liver diseases, and mental diseases." ... > cholesterol and other risk factors related to cardiovascular and all-cause ... > women in relation to age and cause of death. ... showing significant associations with death ...
    (sci.med.cardiology)
  • Re: LDL too low...?
    ... :: LDL is definitely in association with total cholesterol. ... :: non-cardiovascular causes of death i.e. increased cancer risk and ... women in relation to age and cause of death. ... from the age of 50 onward only, low cholesterol was significantly associated ...
    (sci.med.cardiology)
  • Re: Cholesterol and stroke: A paradox
    ... Blood cholesterol and vascular mortality by age, sex, and blood ... Age, sex, and blood pressure could modify the associations of total ...
    (sci.med.cardiology)
  • Re: One more safe alternative to statins
    ... ::: cholesterol in the elderly population. ... ::: would be much more successful approach than statins. ... :: statins do not improve all cause mortality in the elderly. ... women in relation to age and cause of death. ...
    (sci.med.cardiology)
  • Re: British government links statin drugs to 92 deaths
    ... > with lowered cholesterol were more likely to die of cancer. ... death through cancer, liver diseases, and mental diseases." ... J Womens Health. ... women in relation to age and cause of death. ...
    (sci.med.cardiology)