Re: Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercise and Statins.

Impairment of the ubiquitin-proteasome system has been implicated in
neurodegenerative disease, also--it is the primary mechanism of disese
uncovered in inherited form of parkinson's involving the Parkin gene
(Park2) which accounts for most of the inherited forms of Parkinson;'s
thus far discovered:

Klein, C. (2001). "[The genetics of Parkinson syndrome]." Schweiz
Rundsch Med Prax 90(23): 1015-23.
A genetic contribution to the etiology of Parkinson's disease was first
suspected by Charcot and later confirmed by case control, family, and
twin studies, as well as by the description of large parkinsonian
families with Mendelian inheritance of the disease. Recent progress in
the field of molecular neurogenetics has led to the identification of
several Parkinson disease genes and gene loci. Mutations in the
alpha-Synuclein gene (PARK1) and in the gene for the ubiquitin
C-terminal hydrolase I (PARK5), along with two gene loci harboring
currently unknown genes (PARK3 and PARK4), have been linked to very
rare autosomal dominantly inherited parkinsonian syndromes. Mutations
in the parkins gene (PARK2), causing autosomal recessive early-onset
parkinsonism, are much more common and therefore of clinical relevance.
A second gene locus for an autosomal dominantly inherited Parkinsonian
syndrome was recently localized on chromosome 1 (PARK6). All three
parkinson genes identified thus far imply the involvement of the
ubiquitin pathway of protein degradation in the pathogenesis of
Parkinson's disease.

thanks sharon for finding and posting the abstract relating statins to
interruption to the UPS. There are many other published studies and
articles discussing the ubiquitin-proteasome system and its dysfunction
in parkinson's. m

.