Re: Good overview of pantethine, Europe and Japan's safe and effective alternative to statin drugs; Pantethine is considered "atoxic" due to its superior safety profile


Jim Chinnis wrote:
> Susan <nevermind@xxxxxxxxxx> wrote in part:
>
> >Does this help at all?
> >
> > Atherosclerosis. 1987 Nov;68(1-2):41-9. Related Articles, Links
> >
> > Pantethine lipomodulation: evidence for cysteamine mediation in
> >vitro and in vivo.
>
> Yes. If I'm following the abstract, pantethine may not survive long enough
> to have much of a statin effect and instead acts mainly via one of its
> hydrolysis products employing different mechanisms.

Yes to "pantethine may not survive long enough to have much of a
statin effect and instead acts mainly via one of its hydrolysis
products".

So how do you conclude that it employs other mechanisms?

per PMID: 3689482's "Pantethine did increase CoA levels 45% in
rat liver homogenates while equivalent amounts of cystamine or
pantothenate did not." we know that pantethine was hydrolysed.
So cysteamine was produced as the other piece of pantethine.

You are able to conclude that it didn't hydrolyse in PMID: 3196742's
rat liver microsomes with cysteamine being the actual statin there.

....and these other mechanisms show "...equivalent modulation of
cholesterol and methyl sterol synthesis by pantethine, cysteamine..."
at that?

The statin mechanism would be nailed down better if PMID: 3196742
were repeated with cysteamine. I guess that researchers don't
care to bother proving or disproving that.

The other reason I lead you down this trail is:
given the chance that pantethine/hydrolysis products function as a
statin, people ought to be concerned/alert about stacking it with
other (pharma) statins. Reduction in cho synthesis may not be
the only path whereby AEs are caused, but I think its reasonable
expect that it can cause them.

Ed

BTW PMID: 3689482 is related but I don't see it adding much.

.

Relevant Pages

  • Re: Good overview of pantethine, Europe and Japans safe and effective alternative to statin drugs; P
    ... One ought to broaden one's thinking to conceptualize that differing compounds that are unrelated to one another can have some shared effects. ... to have much of a statin effect and instead acts mainly via one of its hydrolysis products employing different mechanisms. ... So cysteamine was produced as the other piece of pantethine. ...
    (sci.med.cardiology)
  • Re: One more safe alternative to statins
    ... Bill wrote: ... cysteamine "modulates cholesterol and methyl sterol synthesis" ... ... "but pantothenate had no effect. ... there when I get more serious about pantethine. ...
    (sci.med.cardiology)
  • Re: Good overview of pantethine, Europe and Japans safe and effective alternative to statin drugs; P
    ... Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. ... Recent human studies suggest rapid in vivo hydrolysis of the lipid-lowering drug, pantethine, to the vitamin pantothenic acid and the small aminothiol compound, cysteamine. ... To test whether the active agent is a hydrolysis product, we repeated three experimental models of pantethine's effect with pantothenate and cysteamine. ... In vitro experiments with human fetal fibroblasts showed equivalent modulation of cholesterol and methyl sterol synthesis by pantethine, cysteamine, or cystamine, but pantothenate had no effect. ...
    (sci.med.cardiology)
  • Re: One more safe alternative to statins
    ... "pantethine is known to be well tolerated" no bias here!!!! ... 6442152 rabbit study irrelevant to human tolerability, ... to possibly start to compare to statin data doesn't state duration ... I would not accept your claims for safety and efficacy of a statin ...
    (sci.med.cardiology)
  • Re: One more safe alternative to statins
    ... >> 5 6442152 rabbit study irrelevant to human tolerability, ... >> to possibly start to compare to statin data doesn't state duration ... >> your claims for pantethine having been proven safer than statins, ...
    (sci.med.cardiology)