Re: LDL cholesterol and diet question

Sat, 17 Dec 2005 21:33:47 +0200 in article
<f1p8q1pj796qgn3r4h1i9gkdcr6u3k2jai@xxxxxxx> Matti Narkia <narkia@xxxxxxxxx>
wrote:
>>
>The final report
>
>Michel de Lorgeril, MD; Patricia Salen, BSc; Jean-Louis Martin, PhD;
>Isabelle Monjaud, BSc; Jacques Delaye, MD; Nicole Mamelle, PhD
>Mediterranean Diet, Traditional Risk Factors, and the Rate of
>Cardiovascular Complications After Myocardial Infarction
>Final Report of the Lyon Diet Heart Study
>Circulation. 1999;99:779-785
><http://circ.ahajournals.org/cgi/content/full/99/6/779>
>
>states:
>
> "Methods and Results?Three composite outcomes (COs)
> combining either cardiac death and nonfatal myocardial
> infarction (CO 1), or the preceding plus major secondary
> end points (unstable angina, stroke, heart failure,
> pulmonary or peripheral embolism) (CO 2), or the
> preceding plus minor events requiring hospital admission
> (CO 3) were studied. In the Mediterranean diet group, CO
> 1 was reduced (14 events versus 44 in the prudent
> Western-type diet group, P=0.0001), as were CO 2 (27
> events versus 90, P=0.0001) and CO 3 (95 events versus
> 180, P=0.0002). Adjusted risk ratios ranged from 0.28 to
> 0.53."
>
>So even in this final report the major cardiovascular events including
>cardiac death and nonfatal myocardial infarction were reduced by 72% (risk
>ratio 0.28 (0.15?0.53), P=0.0001), see also
>
>Table 1. End Points in the 2 Groups and Risk Ratios for the 3 Composite
>Outcomes Calculated With the Cox Proportional-Hazards Model
><http://circ.ahajournals.org/cgi/content-nw/full/99/6/779/T1>.
>
>If other events (which were not mentioned in the abstract of first report)
>such as unstable angina, stroke, heart failure, pulmonary or peripheral
>embolism and minor events requiring hospital admission are included, then
>risk ratios vary down to 0.53.

Some thrombotic events, for example pulmonary or peripheral
embolism, may happen even the absence of atherosclerosis. Perhaps some
antithrombotic food items such as ginger and cocoa powder or dark chocolate
could improve Cretan traditional Mediterranean diet in this respect.

Other candidates for improvement of Cretan traditional Mediterranean diet:
replacing coffee with green tea, using turmeric as a spice or/and curcumin
as a supplement.

--
Matti Narkia
.

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