Re: Lipitor did not prevent cardiovascular events or death in patients with type 2 diabetes receiving hemodialysis


"David Rind" <drind@xxxxxxxxxxxxxxxxxxxxx> wrote in message
news:drk4gc$a7f$1@xxxxxxxxxxxxxxxxxxxx
> Sharon Hope wrote:
>> David,
>>
>> see the Subject line of my post. That is precisely what it says.
>>
>> "Lipitor did not prevent cardiovascular events or death in patients with
>> type 2 diabetes receiving hemodialysis"
>
> As in the past, I'll try once more and then stop since it's clearly not
> worth it.
>
> Your subject line is from the article in ACP Journal Club and is correct.
> You, however wrote (and I left the thread below so you can clearly see
> this):
>
> >Since this study finds Lipitor does not prevent cardiovascular events or
> >death in diabetic patients, why subject them to the adverse effects of
> >peripheral neuopathy when they are already at greater risk already?
>
> Again, this is not what the study found. Leaving out that these were
> patients on hemodialysis (in the above sentence) completely distorts the
> finding of this study. The question you are asking above assumes something
> that is not true.
>

David,
This study is not the only study on statins in existence.

Bringing in other well-established evidence of the existence of statin AEs
and the existence of PN as a well-established diabetic problem is a comment
prompted by the generalized topic at hand.

The concern about prescribing a class of drugs proven to cause PN to a
population at great risk of PN is a concern that existed since the FDA
debated opening the diabetic market to the statin manuafacturers.

The rhetorical question can be expanded, but OK, if you choose to apply it
only to people who have type 2 diabetes AND are on hemodialysis, the
question still stands. Why market to this rarified population, when 1)
there is no evidence of benefit and 2) PN risk is increased?



>>
>>
>> "David Rind" <drind@xxxxxxxxxxxxxxxxxxxxx> wrote in message
>> news:drji9j$2gl$1@xxxxxxxxxxxxxxxxxxxx
>>
>>>Sharon Hope wrote:
>>>
>>>>Statins cause peripheral neuropathy.
>>>>
>>>>Diabetics have problems with peripheral neuropathy that can lead to
>>>>amputation.
>>>>
>>>>Since this study finds Lipitor does not prevent cardiovascular events or
>>>>death in diabetic patients, why subject them to the adverse effects of
>>>>peripheral neuopathy when they are already at greater risk already?
>>>>
>>>>Where is the outcry? What has happened to medical ethics?
>>>
>>>You are misunderstanding the study. It WAS NOT about the use of statins
>>>to prevent cardiovascular events or death in diabetic patients. Multiple
>>>studies have found that statins clearly do prevent both of these outcomes
>>>in diabetics.
>>>
>>>The study found little evidence that statins prevent these outcomes in
>>>diabetics WHO ARE ON DIALYSIS. This is a tiny subset of people with
>>>diabetes.
>>>
>>>--
>>>David Rind
>>>drind@xxxxxxxxxxxxxxxxxxxxx
>
>
> --
> David Rind
> drind@xxxxxxxxxxxxxxxxxxxxx


.

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