Re: Statins and side effects......Statin Mitochondrial Cytopathy & CoQ10 Deficiency


"listener" <listener@xxxxxxxxxx> wrote in message
news:Xns976227371282some1outthere@xxxxxxxxxxxxxxxxxx
You're a chronic cherry picker

Which of these studies do you consider to be cherries?

STATINS & MITOCHONDRIAL CYTOPATHY,
COENZYME Q10 (UBIQUINONE) DEFICIENCY CAUSED BY STATINS
Do statins cause a CoQ10 deficiency?


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12353945&dopt=Abstract

Study report: http://www.annals.org/issues/v137n7/nts/200210010-00004.html

Dr. Phillips study mentioned in a Wall Street Journal article (This is
smooth muscle, not cardiac muscle.) Conclusion "statin therapy may be
associated with increased oxidation injury.mild adverse effects of statins
that are difficult to assess might be much more prevalent than widely
considered "

http://www.impostertrial.com Is Myopathy Part Of Statin Therapy? Dr.
Phillips study website, with info for Patient and Physician



Cohen & Gold, Mitochondrial Cytopathy in Adults: What we know so far

http://www.ccjm.org/pdffiles/COHEN701.PDF

(See "Heart" in table page 4, and section on page 7) CoQ10 If statins cause
CoQ10 deficiency, and CoQ10 deficiency causes mitochondrial disease, what
are the symptoms of mitochondrial disease? Heart pain is one of them.

Oxidation Injury in Patients Receiving HMG-CoA Reductase Inhibitors:
Occurrence in Patients without Enzyme Elevation or Myopathy.



US Patents: # 4,933,165

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=50&s1=4933165.WKU.&OS=PN/4933165&RS=PN/4933165



see also subsequent related patents: Do a search by patent number at:

http://patft.uspto.gov/netahtml/srchnum.htm

for the following:

United States Patent 5,082,650

United States Patent 5,849,777

United States Patent 6,264,960

Merck Patent application stating that statins interfere with CoQ10 and that
deficiency causes problems. They documented that they knew this about
statins in 1989, 10 years before the 100+ deaths by Rhabdomyolysis!



http://sites.huji.ac.il/malaria/maps/ubiquinonemetpath.html

Malaria Parasite Metabolic Pathways Ubiquinone Metabolism

another version:

http://www.stdgen.lanl.gov/stdgen/images/KEGG/00130.html

DEFINITION Ubiquinone biosynthesis - Reference pathway. Diagram of the
Ubiquinone (aka CoQ10) metabolic pathway, highlighting exactly where the
Statins interrupt it. All of the 17 or so steps have to happen correctly for
the body to produce CoQ10, but statins interrupt (or retard) this in step
#2.



Introduction to the Citizen's petition to the FDA:
http://www.vaccinationnews.com/DailyNews/July2002/StatinInduced8.htm by Dr.
Peter Langsjoen This is the introduction to the petition. (It is aimed at
getting attention, and the wording may be more alarming than necessary.)



To the FDA: "Citizen Petition To Change The Labeling For All Statin Drugs
(Mevacor, Lescol, Pravachol, Zocor, Lipitor, And Advicor) Recommending Use
Of 100-200mg Per Day Of Supplemental Co-Enzyme Ql0 To Reduce The Risk Of
Statin-Induced Myopathies (Including Cardiomyopathy And Congestive Heart
Failure)," by Dr. Julian Whitaker, MD:
http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf
or as html:
http://216.239.33.100/search?q=cache:4qAiX-YbZLYC:www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf+Statin-Induced+Cardiomyopathy+Introduction+To+The+Citizen%27s+Petition+On+Statins&hl=en&ie=UTF-8

Statin Depletion of CoQ10 is linked to heart problems.

Exhibit A of FDA Petition: "The clinical use of HMG CoA-reductase inhibitors
(statins) and the associated depletion of the essential co-factor coenzyme
Ql0; a review of pertinent human and animal data." by Dr. Peter Langsjoen
MD:
http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-02-Exhibit_A-vol1.pdf



Effect of atorvastatin on left ventricular diastolic function and ability of
coenzyme Q10 to reverse that dysfunction.

Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A.

Am J Cardiol. 2004 Nov 15;94(10):1306-10.

Heart Failure Institute, Department of Medicine, Advocate Christ Medical
Center, University of Illinois/Christ Cardiovascular Disease Fellowship
Program, Oak Lawn, Illinois 60453, USA. marc.silver@xxxxxxxxxxxxxxxxxx
<marc.silver@xxxxxxxxxxxxxxxxxx>

"This study evaluated left ventricular diastolic function with Doppler
echocardiography before and after statin therapy. Statin therapy worsened
diastolic parameters in most patients; coenzyme Q(10) supplementation in
patients with worsening diastolic function with statin therapy improved
parameters of diastolic function."





Examples of the heart and other problems associated with statin depletion of
CoQ10.



1: Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A.

Effect of atorvastatin on left ventricular diastolic function and ability
of

coenzyme Q10 to reverse that dysfunction.

Am J Cardiol. 2004 Nov 15;94(10):1306-10.

PMID: 15541254 [PubMed - indexed for MEDLINE]



2: Rundek T, Naini A, Sacco R, Coates K, DiMauro S.

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at
risk

for cardiovascular disease and stroke.

Arch Neurol. 2004 Jun;61(6):889-92.

PMID: 15210526 [PubMed - indexed for MEDLINE]



3: Ornato JP.

Questions & answers. I take a statin to lower my LDL (bad) cholesterol
level,

but I've heard statins inhibit the production of coenzyme Q10 (CoQ10).
Should I

take a CoQ10 supplement?

Health News. 2004 Apr;10(4):16. No abstract available.

PMID: 15088591 [PubMed - indexed for MEDLINE]



4: Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A.

Statin cardiomyopathy? A potential role for Co-Enzyme Q10 therapy for

statin-induced changes in diastolic LV performance: description of a
clinical

protocol.

Biofactors. 2003;18(1-4):125-7.

PMID: 14695927 [PubMed - indexed for MEDLINE]



5: Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP.

Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting

other antioxidants and PUFA.

Biofactors. 2003;18(1-4):113-24.

PMID: 14695926 [PubMed - indexed for MEDLINE]



6: Langsjoen PH, Langsjoen AM.

The clinical use of HMG CoA-reductase inhibitors and the associated
depletion

of coenzyme Q10. A review of animal and human publications.

Biofactors. 2003;18(1-4):101-11. Review.

PMID: 14695925 [PubMed - indexed for MEDLINE]



7: Pettit FH, Harper RF, Vilaythong J, Chu T, Shive W.

Reversal of statin toxicity to human lymphocytes in tissue culture.

Drug Metabol Drug Interact. 2003;19(3):151-60.

PMID: 14682607 [PubMed - indexed for MEDLINE]



8: Wolters M, Hahn A.

Plasma ubiquinone status and response to six-month supplementation combined

with multivitamins in healthy elderly women--results of a randomized,

double-blind, placebo-controlled study.

Int J Vitam Nutr Res. 2003 May;73(3):207-14.

PMID: 12847998 [PubMed - indexed for MEDLINE]



9: Hargreaves IP.

Ubiquinone: cholesterol's reclusive cousin.

Ann Clin Biochem. 2003 May;40(Pt 3):207-18. Review.

PMID: 12803831 [PubMed - indexed for MEDLINE]



10: [No authors listed]

Extra co-enzyme Q10 for statin-users?

Treatmentupdate. 2001 Jun;13(2):4-7.

PMID: 11570288 [PubMed - indexed for MEDLINE]



11: Fosslien E.

Mitochondrial medicine--molecular pathology of defective oxidative

phosphorylation.

Ann Clin Lab Sci. 2001 Jan;31(1):25-67. Review.

PMID: 11314862 [PubMed - indexed for MEDLINE]



12: Kaikkonen J, Nyyssonen K, Tomasi A, Iannone A, Tuomainen TP,

Porkkala-Sarataho E, Salonen JT.

Antioxidative efficacy of parallel and combined supplementation with
coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects:
a randomized

placebo-controlled clinical study.

Free Radic Res. 2000 Sep;33(3):329-40.

PMID: 10993487 [PubMed - indexed for MEDLINE]



13: Levin WM.

Statin drugs: a double-edged sword?

Hosp Pract (Off Ed). 1997 Aug 15;32(8):44. No abstract available.

PMID: 9275961 [PubMed - indexed for MEDLINE]



14: De Pinieux G, Chariot P, Ammi-Said M, Louarn F, Lejonc JL, Astier A,

Jacotot B, Gherardi R.

Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA
reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.

Br J Clin Pharmacol. 1996 Sep;42(3):333-7.

PMID: 8877024 [PubMed - indexed for MEDLINE]



15: Fjelstrup A.

[Statin therapy and heart failure. There is a difference between statins]

Tidsskr Nor Laegeforen. 1994 May 20;114(13):1561-2. Norwegian. No abstract

available.

PMID: 8079255 [PubMed - indexed for MEDLINE]



16: Carlsen SM, Fougner KJ.

[Statin therapy, Q10 and heart failure. Is there any difference between
statins?]

Tidsskr Nor Laegeforen. 1994 Apr 30;114(11):1345. Norwegian. No abstract

available.

PMID: 8079217 [PubMed - indexed for MEDLINE]



17: Hyams DE, Roylance PJ, Kruger K, Bodd E.

[Do we kill our cardiac patients with statin therapy? Coenzyme Q10, what do
we know?]

Tidsskr Nor Laegeforen. 1994 Feb 20;114(5):590. Norwegian. No abstract

available.

PMID: 7748252 [PubMed - indexed for MEDLINE]





http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2247468&dopt=Abstract

Lovastatin decreases coenzyme Q levels in humans.

Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4.

PMID: 2247468 [PubMed - indexed for MEDLINE] A 1990 study showing depletion
of CoQ10 by Lovastatin - includes descriptions of cardiac patients.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11479481&dopt=Abstract A
2001 discussion on "The effect of pravastatin and atorvastatin on coenzyme
Q10"



http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellularRespiration.html
Primer on how cells breathe normally (Note the role of CoQ10, called
"Ubiquinone" in "The Respiratory Chain" section.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11505177&dopt=Abstract
(abstract)

http://213.4.18.135/70.pdf

http://216.239.33.100/search?q=cache:IGxCBJ3vs1kC:213.4.18.135/70.pdf+gaist+statin+myopathy+risk+greater&hl=en&ie=UTF-8
view as html

Lipid-lowering drugs and risk of myopathy: a population-based follow-up
study. Dr. Gaist is in Denmark and studies populations of entire countries
for epidemiology information.



http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12011277&dopt=Abstract
Dr. Gaist's study, Statins and risk of polyneuropathy: a case-control study.
(more serious than peripheral neuropathy)

http://213.4.18.135/87.pdf Dr. Gaist's studies on Statin-induced nerve
damage (full text)



Others:

Watts GF, Castelluccio C, Rice-Evans C, Taub NA, Baum H, Quinn PJ. Plasma
coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin.

J Clin Pathol. 1993;46:1055-7. [PMID: 8254097]

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=PMID&colon;
8254097



Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum
coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.

Mol Aspects Med. 1997;18 Suppl:S137-44. [PMID: 9266515]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=9266515





Bargossi AM, Grossi G, Fiorella PL, Gaddi A, Di Giulio R, Battino M.
Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced
by HMG-CoA reductase inhibitors. Mol Aspects Med. 1994;15 Suppl:s187-93.
[PMID: 7752830]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=7752830



Ogasahara S, Engel AG, Frens D, Mack D. Muscle coenzyme Q deficiency in
familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A.
1989;86:2379-82. [PMID: 2928337]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=2928337



Baker SK, Tarnopolsky MA. Statin myopathies: pathophysiologic and clinical
perspectives. Clin Invest Med. 2001;24:258-72. [PMID: 11603510]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=11603510



Rosenfeldt FL, Pepe S, Ou R, Mariani JA, Rowland MA, Nagley P, et al.
Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic
and ischemic stress: studies in rats and in human atrial tissue. Biofactors.
1999;9:291-9. [PMID: 10416043]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=10416043



Reust CS, Curry SC, Guidry JR. Lovastatin use and muscle damage in healthy
volunteers undergoing eccentric muscle exercise. West J Med.
1991;154:198-200. [PMID: 2006566]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=2006566



Statin-associated myopathy.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12672737&dopt=Abstract

Thompson PD, Clarkson P, Karas RH.

Preventive Cardiology and Cardiovascular Research, Division of Cardiology,
Hartford Hospital, Hartford, Conn 06102, USA. pthomps@xxxxxxxxxxxx

"recent evidence suggests that statins reduce the production of small
regulatory proteins that are important for myocyte maintenance"



Statins and myotoxicity.

Curr Atheroscler Rep. 2003 Mar;5(2):96-100. Review.

PMID: 12573193 Farmer JA.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12573193&dopt=Abstract

Baylor College of Medicine, One Baylor Plaza, Room 525D, Houston, TX 77030,
USA. jfarmer@xxxxxxxxxxx





CARNITINE DEFICIENCY CAUSED BY STATINS
Can statins cause carnitine deficiency?
Bhuiyan J, Seccombe DW. The effects of 3-hydroxy-3-methylglutaryl-CoA
reductase inhibition on tissue levels of carnitine and carnitine
acyltransferase activity in the rabbit. Lipids. 1996;31:867-70. [PMID:
8869889]
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=8869889


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