Re: Statins and side effects......Statin Damage to Immune System


"listener" <listener@xxxxxxxxxx> wrote in message
news:Xns976227371282some1outthere@xxxxxxxxxxxxxxxxxx
You're a chronic cherry picker

Which of these studies do you consider to be cherries?

IMMUNE SYSTEM AND STATINS
Frequently Asked Question: Can statins depress my immune system?


It is a tribute to the imaginations of the drug marketers to see how
successfully they have put positive "spin" on a very alarming proposition,
that statins depress the immune system (or is it just arrogance?). If the
known side effect of statins is to depress your immune system, and it is so
beneficial to transplant recipients and others with autoimmune disease, what
about people with pre-statin 'normal' immune systems?

I'm not the only one astonished and disgusted with this, check out Dr.
Mercola's comment (scroll down for his response to the article) on
http://www.mercola.com/2000/dec/24/statins.htm

Excerpts: "This is an amazing example of positive "spin" put on a very
negative result. People with high cholesterol certainly don't need their
immune systems suppressed...If suppressing the helper T cells is considered
such great benefit then there is a disease going around that does this quite
well - AIDS...if the mechanism of action of the drug is not understood, how
can the manufacturer or the FDA claim that it is safe"

It sounds like he is talking about this article



http://pub.ucsf.edu/today/print.php?news_id=200211062 , but actually he is
describing the last time the drug companies tried to feed us a myth about
how great it is that statins depress immune systems: (available for online
purchase from Nature Medicine:

http://www.nature.com/dynasearch/app/dynasearch.taf?sp-w=Exact&_action=search&search_fulltext=&sp-p=All&search_volume=&search_startpage=&search_title=&search_author=&search_abstract=statins+as+immunosuppressors&issue_start_month=12&issue_start_year=2000&issue_end_month=01&issue_end_year=2001&pickerCount=You+have+selected+1+journal+to+search.&rolloverMessage=&sp_k=NM

Atorvastatin suppresses interferon-gamma -induced neopterin formation and
tryptophan degradation in human peripheral blood mononuclear cells and in
monocytic cell lines.

Neurauter G, Wirleitner B, Laich A, Schennach H, Weiss G, Fuchs D.

Summary: Recent findings indicate that statins also have anti-inflammatory
properties and can modulate the immune response.statins inhibit T cell
activation within the cellular immune response.atorvastatin directly
inhibits IFN-gamma-mediated pathways in monocytic cells, suggesting that
both immunoreactivity of T cells and of monocyte-derived macrophages are
down-regulated by this statin.

Clin Exp Immunol 2003 Feb;131(2):264-7

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12562386&dopt=Abstract



A novel anti-inflammatory role for simvastatin in inflammatory arthritis.

Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H, Madhok R,
Campbell C, Gracie JA, Liew FY, McInnes IB.

J Immunol. 2003 Feb 1;170(3):1524-30.

PMID: 12538717 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12538717&dopt=Abstract



Immunomodulation: a new role for statins?

Wulf Palinski

SUMMARY: Statins reduce the expression of the class II major
histocompatibility complex (MHCII) by arterial cells, leading to a decreased
T-cell response. This indicates that statins...

Nature Medicine6, 1311 - 1312 (01 Dec 2000) News and Views



HMG-CoA reductase inhibitors as immunomodulators: potential use in
transplant rejection.

Raggatt LJ, Partridge NC.

These findings suggest that statins have the potential to regulate an immune
response in vivo and that more investigation is essential in order to
explain the opposing clinical data.

Drugs. 2002;62(15):2185-91.

PMID: 12381218 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12381218&dopt=Abstract



Statins as a newly recognized type of immunomodulator

Brenda Kwak, Flore Mulhaupt, Samir Myit, François Mach

SUMMARY: Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase, or statins, are effective lipid-lowering agents, extensively used
in medical practice. Statins have never been shown to...

Nature Medicine 6, 1399 - 1402 (01 Dec 2000) Article



Could a depressed immune system lead to infection? See:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11936540&dopt=Abstract

Statin-induced fibrotic nonspecific interstitial pneumonia.

Eur Respir J. 2002 Mar;19(3):577-80.

PMID: 11936540 [PubMed - indexed for MEDLINE]


.

Relevant Pages

  • Re: Heart Drugs May Target AIDS Virus, Study Shows
    ... Statin drugs are known to depress the immune system. ... But, then, statins are known to cause peripheral neuropathy, and are now ... > web sites) virus, ... > suppressed the virus and helped replenish immune cells known as T-cells ...
    (sci.med.cardiology)
  • Re: Heart Drugs May Target AIDS Virus, Study Shows
    ... Can statins depress my immune system? ... It is a tribute to the imaginations of the drug marketers to see how ... HMG-CoA reductase inhibitors or fibrates drugs have been reported. ...
    (sci.med.cardiology)
  • Re: Statins may Protect Against Pneumonia Fatalities
    ... established adverse effect of statins: suppression of the immune system. ... combination drug, Vytorin, with both Zetia and Zocor ... For a full FAQ of statin adverse effects, ...
    (sci.med.cardiology)
  • Re: Statins may Protect Against Pneumonia Fatalities
    ... > established adverse effect of statins: suppression of the immune system. ... cases the immune response to infection is worse than the infection. ... to some people we may give statins. ...
    (sci.med.cardiology)
  • Re: Bogus statin pleiotropic claims
    ... BTW, not only did statins NOT benefit AIDS patients, statins are proven to ... damage the immune system. ...
    (sci.med.cardiology)
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