Re: Statins and side effects......Statins and the elderly


"listener" <listener@xxxxxxxxxx> wrote in message
news:Xns976227371282some1outthere@xxxxxxxxxxxxxxxxxx
You're a chronic cherry picker

Which of these studies do you consider to be cherries?

ELDERLY AND STATINS
Frequently Asked Question: Should people over 70 take statins?


Lack of association between cholesterol and coronary heart disease mortality

and morbidity and all-cause mortality in persons older than 70 years.

JAMA. 1994 Nov 2;272(17):1335-40.

Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V,

Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF.

Department of Internal Medicine, Yale University School of Medicine, New

Haven, CT 06520-8017.



"CONCLUSIONS--Our findings do not support the hypothesis that

hypercholesterolemia or low HDL-C are important risk factors for all-cause

mortality, coronary heart disease mortality, or hospitalization for

myocardial infarction or unstable angina in this cohort of persons older

than 70 years."



Another study showing people over 65 do not benefit from cholesterol

reduction:



Long-Term Prognostic Importance of Total Cholesterol in Elderly Survivors of

an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot

Project.

Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM.

Section of Cardiovascular Medicine, Department of Medicine, and Section of

Chronic Disease Epidemiology, Department of Epidemiology and Public Health,

Yale School of Medicine, New Haven, Connecticut; Qualidigm, Middletown,

Connecticut; Yale-New Haven Hospital Center for Outcomes Research and

Evaluation, New Haven, Connecticut; Center for Outcome and Effectiveness

Research and Education, University ofAlabama at Birmingham and Birmingham

Veterans Affairs Medical Center, Birmingham, Alabama; Department of

Preventive Medicine, University of Kansas School of Medicine, Kansas City,

Kansas; and Metastar, Madison, Wisconsin.

J Am Geriatr Soc. 2003 Jul;51(7):930-936. PMID: 12834512



"PARTICIPANTS: Four thousand nine hundred twenty-three Medicare

beneficiaries from four states aged 65 and older"



"CONCLUSION: Among elderly survivors of AMI, elevated total serum

cholesterol measured postinfarction is not associated with an increased risk

of all-cause mortality in the 6 years after discharge. Furthermore, this

study found no evidence of an increased risk of all-cause mortality in

patients with low total cholesterol. Further studies are needed to determine

the relationship of postinfarction lipid subfractions and mortality in older

patients with coronary artery disease (CAD)."



High-density vs low-density lipoprotein cholesterol as the risk factor for
coronary artery disease and stroke in old age.

Weverling-Rijnsburger AW, Jonkers IJ, van Exel E, Gussekloo J, Westendorp
RG.

Section of Gerontology and Geriatrics, Department of General Internal
Medicine, Leiden University Medical Center, Leiden, The Netherlands.
a.w.e.weverling-rijnsburger@xxxxxxxx

Arch Intern Med. 2003 Jul 14;163(13):1549-54.



http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12860577&dopt=Abstract



"In contrast to high LDL cholesterol level, low HDL cholesterol level is a
risk factor for mortality from coronary artery disease and stroke in old
age."



Total cholesterol and risk of mortality in the oldest old.

Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, Knook DL, Meinders AE,
Westendorp RG.

Department of General Internal Medicine, Leiden University Medical Center,
The Netherlands.

Lancet. 1997 Oct 18;350(9085):1119-23.



" In people older than 85 years, high total cholesterol concentrations are
associated with longevity owing to lower mortality from cancer and
infection. The effects of cholesterol-lowering therapy have yet to be
assessed."



Golomb BA, Criqui MH, White HL, Dimsdale JE.

The UCSD Statin Study: a randomized controlled trial assessing the impact
of statins on selected noncardiac outcomes.

Control Clin Trials. 2004 Apr;25(2):178-202.

PMID: 15020036 [PubMed - indexed for MEDLINE]



Algotsson A, Winblad B.

Patients with Alzheimer's disease may be particularly susceptible to
adverse effects of statins.

Dement Geriatr Cogn Disord. 2004;17(3):109-16. Epub 2004 Jan 20. Review.

PMID: 14739530 [PubMed - indexed for MEDLINE]






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