New genetics study to augment Framingham data

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Bill

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New genetics study to augment Framingham data

Feb 13, 2006 Caroline Cassels

Bethesda, MD - The launch of a new genetic research study to identify genes
underlying cardiovascular and other chronic diseases will take the
world-famous Framingham Heart Study to the next level, scientists say.

Launched by the National Heart, Lung, and Blood Institute (NHLBI) of the
National Institutes of Health (NIH) and Boston University, the Framingham
Genetic Research Study will involve up to 500 000 genetic DNA analyses of 9000
study participants across three generations.

The new study will build on knowledge gained from the Human Genome Project and
from the recently completed HapMap Project, which charted the pattern of
genetic variation in the human genome. The Framingham Genetic Research Study
will use new technology that allows rapid genotyping of approximately 500 000
single nucleotide polymorphisms (SNPs) in each individual.

According to NHLBI director Dr Elizabeth Nabel, the study will accelerate
discoveries on the causes, prevention, and treatment of major chronic
diseases. "Using the latest technology, researchers will be able to obtain
more information about the connection between unique genetic variations in DNA
and cardiovascular-disease risk factors, as well as the genetic basis for
heart attack, stroke, and other chronic diseases," she said in an NHLBI
release.



International research impact
In addition, the NIH National Center for Biotechnology Information, which is
part of the NIH Library of Medicine, will help develop a study database that
will be made available at no cost to investigators throughout the world,
providing opportunities for other scientists to explore associations between
genes and specific diseases.

Ultimately, said Fox, the hope for the project is that it will result in the
identification of genes responsible for many chronic diseases and lead to the
development of new prevention and treatment strategies.



Related link


Gene that predisposes to type 2 diabetes discovered
[HeartWire > Metabolic syndrome; Jan 19, 2006]




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