Re: Methionine increases heart disease risk
- From: "Robert" <Robertsnospam2@xxxxxxxxxxx>
- Date: Fri, 17 Mar 2006 02:38:43 -0800
"Knack" <zymatik@xxxxxxxxxxxxxxx> wrote in message
Don't worry about serum homocysteine levels.
Homocysteine is an independent risk factor along with CRP. Just because one
can reduce these markers does not mean they can not be used in risk
assessment.
An important conclusion that is *not* reported about these NEJM studies isof
that the latest scientific evidence shows homocysteine not to be a cause
cardiovascular disease;
Cause and risk factor are two different things. Risk factors are cumulative.
The more you have the greater the chance.
it can simply be a marker of it during a diet that
does not include heavy vitamin B supplementation.
That appears to be the case. Heavy B vitamins are not really recommended
Also, moderate coffee
consumption (due to both caffeine and chlorogenic acid) can increase
homocysteine level without causing cardiovascular disease.
No reference for that?
IOW, high homocysteine level can be an effect of either moderately high
consumption of coffee, and/or red meat.
There are genetic variants of inborn errors of metabolism that can elevate
Homocysteine including homocysteinuria and homocysteinemia. There is folate
and B12 deficiency that can elevate homocysteine. Only methylmalonate is
increased in B12 and not in folate deficiency. There's a few of other
conditions including oral contraceptives, smoking and hypothyroidism and
renal failure.
Samples collected in serum can elevate values and it should be repeated
using whole blood plasma samples if high.
Or it could be an effect of
cardiovascular disease, but not the cause of that. Moreover, whenUntil
supplementing with heavy doses of B vitamins, that effect disappears.
the studies that I've cited above, it had been presumed that highidea
homocysteine translated to increased cardiovascular risk, but now that
has been dispelled.
I don't see that interpretation. High homocysteine is a marker and not a
cause of increased cardiovascular disease.
If an association is established by previous studies these new studies do
not dispell them.
The reference range for homocysteine is established like any other reference
or normal range for a test. You get normal people, and that would include
coffee drinkers and those taking vitamins and get an average. Calculate 2
and 3 standard deviations and set the reference interval.
You then get sick people and look at their values.
Clinical cut-off values are values which differentiate between disease and
non-disease or minimal risk, moderate risk and high risk.
.
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