Re: Take 80 mg aspirin in AM or PM?

In article <eak1525h9pjta1fc5mte1m61lj4ipuadl4@xxxxxxx>, me@xxxxxxxxxxx
wrote:

Joe Doe <None@xxxxxxxxxxxxxxx> wrote:

Many people feel taking
Lipitor at night is preferable.

Really?

How come?

Is that a good idea to start doing?


The reason was already posted in another reply - cholesterol synthesis
by the liver is maximum at night and peak amounts of the drug which
inhibits this synthesis will coincide. The half life of atorvastatin is
14 hours but the half life of inhibitory action is 20-30 hours because
the metabolites are also active with respect to inhibition (70% of the
inhibitory action is attributed to metabolites). Because of the long
lived metabolites the precise time when you take lipitor is not critical
but is probably still preferable to take it at night for the reasons
outlined.

Roland
.