Re: Statins and muscle damage

David Rind wrote:

A blood test is unlikely to be of help since people can have
high muscle enzyme values without injury and normal values
despite injury

However, depending on how we are defining "injury", is it not
fair to say that if (1) there is no enzyme elevation, and (2)
there are no symptoms, then there is no injury? Or in other
words, no need to worry?

A couple of caveats, of course: A. Although there may be no
current injury, the future remains unpredictable, and muscle
symptoms (which are nearly always mild and reversible) may arise
at any time.

B. Some people** have chosen to identify high levels of
prostaglandin F as indicating statin-induced "oxidative injury",
which may therefore be a marker of a concealed form of muscle or
other damage. The evidence for this seems to me weak,
circumstantial and lacking clinical relevance, but it's an area
that needs more work.

David Rollo

** Sinzinger H et al (2002) Drug Safety 25:877-883

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