Re: Atenelol and weight loss

Susan <nevermind@xxxxxxxxxx> wrote:

Guy Scharf wrote:

Could the Atenelol have been partially responsible for the
plateau?

Atenolol promotes weight gain:


(Hypertension. 2001;37:250.)
© 2001 American Heart Association, Inc.
Scientific Contributions
Hypothesis: ß-Adrenergic Receptor Blockers and Weight Gain
A Systematic Analysis
Arya M. Sharma; Tobias Pischon; Sandra Hardt; Iris Kunz; Friedrich
C. Luft

From the Franz Volhard Clinic and Max Delbrück Center for
Molecular
Medicine, Medical Faculty of the Charité, Humboldt University,
Berlin, Germany.

Correspondence to Arya M. Sharma, MD, Franz Volhard Clinic,
Wiltbergstrasse 50,13125, Berlin, Germany. E-mail
sharma@xxxxxxxxxxxxx

One of the arguments put forward against the primary use of
ß-blockers has been concern about adverse metabolic effects, such
as unfavorable effects on lipids or insulin sensitivity. Another
less-appreciated potential drawback is their propensity to cause
weight gain in some patients. In 8 evaluable prospective
randomized controlled trials that lasted >=6 months, body weight
was higher in the ß-blocker than in the control group at the end
of the study. The median difference in body weight was 1.2 kg
(range -0.4 to 3.5 kg). A regression analysis suggested that
ß-blockers were associated with an initial weight gain during the
first few months. Thereafter, no further weight gain compared with
controls was apparent. There was no relationship between
demographic characteristics and changes in body weight. Based on
these observations, the first-line use of ß-blockers in obese
hypertensive patients should be reviewed. Obesity management in
overweight hypertensive patients may be more difficult in the face
of ß-blocker treatment.


Key Words: obesity ? ß-blockers ? body weight ? hypertension,
obesity



I'm a type 2 DM, too, with a strong family history of CVD. I've
been able to keep my bg tightly controlled and my lipids
dramatically improved with diet alone. I've found a couple of
very well studied supplements that also promote insulin
sensitivity and lipid improvements, and without unfortunate side
effects.

My rule: if a medicine makes you feel worse, don't take it, it's
bad for you.

Susan,

Thank you very much for the reference.

Do you know if there is a relationship between atenelol and sleep?
I've found that since stopping the atenelol that I have been sleeping
more deeply and dreaming a lot more.

I agree completely with your rule about medicines! I'm very sensitive
to my reactions and stop medicines quickly. As a result, I have a
growing list of medicines I have allergic or negative reactions to.
From talking with others, I think some people just suffer through the
reactions. I have tried three statins, with significant negative
reactions to all of them.

When I get my weight down to into a desirable range, I'm going to re-
evaluate the DM medicines I am taking and reduce dosages or eliminate
them if possible. My doctor fully supports my doing that, and has
even recommended stopping meds occasionally to see if they are still
needed. I recently had to stop the metformin for several days and the
BG readings during that period atest that I'm not ready to eliminate
that medication yet! :-)

My lipids are now barely within the normal range and I've been able to
partially address the HDL/Trig ratio problem typical of Metabolic
Syndrome with weight loss and exercise. I expect to continue to
improve as weight loss continues. I'm not yet down to the recommended
range for people with DM or CVD though.

I've just started Zetia and will retest lipids after being on that for
a while.

After seeing what the Zetia does, I plan to try Bio-Lipotrol. This
contains Vit B3, Inositol, Guggle Gum extract, Red Yeast Rice extract
and Policosanol. My wife's naturopath says he has seen significant
cholesterol reduction using this supplement. What supplement do you
find useful for reducing cholesterol counts?

Thanks again.

Guy
.

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