Re: High Triglycerides is my only problem... is that ACTUALLY a problem?

x-no-archive: yes

David Rind wrote:

"I don't think you'll find a lot of publications where TG was most
predictive, or where HDL had similar prediction to TC/HDL ratio (both of
which are unusual in the above study)."

Does that strike you as very different from what I wrote above?

I didn't say previously that I did not know of any studies that had found contrary results, I said that you were wrong when you said that TG was considered the most predictive serum lipid in terms of CHD. I'm happy to repeat that you are wrong if you are looking for consistency of posts.

I could, in fact, post lots of studies where TG is not similarly predictive. Presumably you can find these for yourself since you found one of the unusual ones where it was predictive. If you really are having trouble finding these, let me know and I'll post some for you.

TGL with low HDL are consistently more predictive of CVD. Since TGL is a direct marker, mostly, for metabolic syndrome, as is low HDL, that makes perfect sense.

I fully understand that profiteers with a target of low LDL are pumping out far more papers insisting (wrongly) that LDL is a more predictive marker.

You're far more willing to accept their profit tainted conclusions than I am.


There's no particular way to know what percentage of people are missed, since "Diabetes" (type II) is a disease based on a consensus definition. If that definition is based on fasting glucose alone, then all diabetics have a high fasting glucose. If you are suggesting that many people with important levels of insulin resistance fail to meet that particular definition of diabetes, you are correct.

The Rancho Bernardo study found that 70% of older female diabetics (and almost that many males) weren't diagnosed by fbg, but were DM on two hour post prandials. I guarantee you that if they'd tested 1 hour PP, it would've been 100%. FBG doesn't go up until years after PP bg has been in the diabetic range, hence all the IGT folks with advanced DM complications by the time they're diagnosed. I was one of these, and I've never had a fbg above 109.

Further, there is no consensus about DM levels, they're all over the map and all of them are still too high, hence all the IGT folks with complications.

Yes, just losing weight is good for reducing insulin resistance. Being in a catabolic state (on pretty much any common diet) improves insulin resistance as does marked weight loss (as shown in a number of studies of patients after bariatric surgery).

Have you considered the differing effects on metabolism and BG and HbA1c targets of low fat, vs, low carb diets? Low fat diets recommended by the ADA, for instance (Joslin recommends no more than 40% of carbs for DM, with much of that unmetabolized fiber) increase dyslipidemia, particularly the more highly predictive TGLs, a marker for IR.


Again, I'm not disagreeing with your general concerns that people with insulin resistance (and probably everyone) should watch their glycemic load. But that doesn't mean that glycemic load is the only important factor in insulin resistance.


I disagree. Though increasing lean body mass is a good thing to do, it has been shown not to reduce IR. But eating low carb does.

Here is a well researched web site. www.phlaunt.com/diabetes

Susan
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Relevant Pages

  • Re: High Triglycerides is my only problem... is that ACTUALLY a problem?
    ... or where HDL had similar prediction to TC/HDL ratio (both of ... If that definition is based on fasting glucose alone, then all diabetics have a high fasting glucose. ... If you are suggesting that many people with important levels of insulin resistance fail to meet that particular definition of diabetes, ... How one loses the weight makes all the difference in the world. ...
    (sci.med.cardiology)
  • Re: Different meanings of "predict" and thanks for previous help!
    ... a hypothesis was not strictly a prediction. ... Perhaps the word "evidence" assumes/suggests the data has the ability tp ... Because we find that being fat predisposes of getting diabetes later in ... effectively combatting fatness decreases your chance of getting ...
    (sci.lang.translation)
  • Re: Different meanings of "predict" and thanks for previous help!
    ... a hypothesis was not strictly a prediction. ... In example 2, the evidence predicts the ... > Because we find that being fat predisposes of getting diabetes later in ... effectively combatting fatness decreases your chance of getting ...
    (sci.lang.translation)