Re: LDL is 105 doctor advises cholesterol medications, seeking advice.

Jim Chinnis wrote:
"eml" <mmlevy46@xxxxxxxxxxx> wrote in part:



They had only around 200 events in the four years, using about 2000
subjects. Not many.
--
Jim Chinnis Warrenton, Virginia, USA- Hide quoted text -- Show quoted text -

Not many events or not many subjects? or both? or not many events for
the # of subjects?

"the study had 90% power to detect a 32% risk reduction in the primary
composite endpoint"


Sorry for not being clear. My comment was that the diabetic group tested was
pretty healthy, in a cardiovascular sense--the last of your three
possibilities. It is apparently possible to be a type-2 diabetic, have a low
LDL, and be relatively safe from heart disease.

There does seem to be some protection from the Lipitor, but the composite
endpoint chosen and the population chosen certainly didn't result in the
kind of relative or absolute risk reduction I would have expected.

I've read only the abstract, so my comments aren't worth much.
--
Jim Chinnis Warrenton, Virginia, USA

What really seemed to happen in this study (as is happening in many such trials of lipid lowering these days), is that there were a lot of crossovers and dropouts. This combined with a confidence interval that included the relative risks seem in the vast majority of trials of statins probably explains why this trial looks like an outlier.

--
David Rind
drind@xxxxxxxxxxxxxxxxxxxxx
.

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