Effect of weight loss on the postprandial response to high-fat and high-carbohydrate meals in obese women.



Ps postprandial = After dinner

Bill

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Conclusion:Our data suggest that weight loss preferentially affects
postprandial triglyceride metabolism.
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1: Eur J Clin Nutr. 2007 Jan 17; [Epub ahead of print]
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Effect of weight loss on the postprandial response to high-fat and
high-carbohydrate meals in obese women.

? Dallongeville J, Gruson E, Dallinga-Thie G, Pigeyre M, Gomila S,
Romon M.

1Service d'Epidemiologie et Sante Publique, Institut Pasteur de Lille,
INSERM, U744, Lille, Cedex, France.
Objective:To assess the effect of weight loss on the plasma lipid and
remnant-like lipoprotein cholesterol (RLPc) response to a high-fat or a
high-carbohydrate meal in a population of obese women.Design:Nutritional
intervention study.Subjects:Sixteen obese women (mean body mass index
(BMI): 37.6+/-5 kg/m(2)).Methods:Subjects were asked to follow an
energy-restricted diet (800 kcal/day) for 7 weeks, followed by a 1-week
maintenance diet. Before and after weight loss, each participant was
given (in random order) two iso-energetic meals containing either 80%
fat and 20% protein (the high-fat meal) or 80% carbohydrate and 20%
protein (the high-carbohydrate meal). Blood samples were collected over
the following 10-h period. A two-way analysis of variance with repeated
measures was used to assess the effect of the meal and postprandial time
on biological variables and postprandial responses (notably RLPc
levels).Results:Weight loss was associated with a significant decrease
in fasting triglyceride (P=0.0102), cholesterol (P<0.0001), low-density
lipoprotein cholesterol (P=0.0003), high-density lipoprotein-cholesterol
(P=0.0009) and RLPc (P=0.0015) levels. The triglyceride response to the
high-fat meal was less intense after weight reduction than before
(interaction P<0.002). This effect persisted after adjustment on
baseline triglyceride levels. The triglyceride response to the
high-carbohydrate meal was biphasic (i.e. with two peaks, 1 and 6 h
after carbohydrate intake). After adjustment on baseline values, weight
reduction was associated with a trend towards a reduction in the
magnitude of the second triglyceride peak (interaction P<0.054). In
contrast, there was no difference in postprandial RLPc responses before
and after weight loss, again after adjustment on baseline
levels.Conclusion:Our data suggest that weight loss preferentially
affects postprandial triglyceride metabolism.Sponsorship:Insudiet
company (France), Conseil Regional Nord Pas de Calais and Institut
Pasteur de Lille.European Journal of Clinical Nutrition advance online
publication, 17 January 2007; doi:10.1038/sj.ejcn.1602603.
PMID: 17228347 [PubMed - as supplied by publisher]

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