While looking about for info on Eicosanoids (Found in a book Susan Recommended. )

The Book was Protein Power.

Found this.

Bill
....................


"it is proposed that an omega-3 FA biomarker, the omega-3 index
(erythrocyte EPA+DHA) be considered at least a marker, if not a risk
factor, for coronary heart disease, especially sudden cardiac death."

1: Pharmacol Res. 2007 Jan 25; [Epub ahead of print]
  Links
Omega-3 fatty acids and cardiovascular disease: A case for omega-3 index
as a new risk factor.
? Harris WS.
Nutrition and Metabolic Disease Research Institute, Sanford
Research/USD, Sanford School of Medicine of the University of South
Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, United States.
The omega-3 fatty acids (FAs) found in fish and fish oils
(eicosapentaenoic and docosahexaenoic acids, EPA and DHA) have been
reported to have a variety of beneficial effects in cardiovascular
diseases. Ecological and prospective cohort studies as well as
randomized, controlled trials have supported the view that the effects
of these FAs are clinically relevant. They operate via several
mechanisms, all beginning with the incorporation of EPA and DHA into
cell membranes. From here, these omega-3 FA alter membrane physical
characteristics and the activity of membrane-bound proteins, and once
released by intracellular phospholipases, can interact with ion
channels, be converted into a wide variety of bioactive eicosanoids, and
serve as ligands for several nuclear transcription factors thereby
altering gene expression. In as much as blood levels are a strong
reflection of dietary intake, it is proposed that an omega-3 FA
biomarker, the omega-3 index (erythrocyte EPA+DHA) be considered at
least a marker, if not a risk factor, for coronary heart disease,
especially sudden cardiac death. The omega-3 index fulfils many of the
requirements for a risk factor including consistent epidemiological
evidence, a plausible mechanism of action, a reproducible assay,
independence from classical risk factors, modifiability, and most
importantly, the demonstration that raising tissue levels will reduce
risk for cardiac events. For these and a number of other reasons, the
omega-3 index compares very favourably with other risk factors for
sudden cardiac death.
PMID: 17324586 [PubMed - as supplied by publisher]

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