pre-hypertension

The association between pre-hypertension status and oxidative stress
markers related to atherosclerotic disease: The ATTICA study

Chrysohoou et al.

Atherosclerosis May 2007

Abstract:

Background
We sought to evaluate the association between pre-hypertension status
and oxidative stress markers (total antioxidant capacity (TAC) and
oxidized low density lipoprotein (LDL)), in a random sample of
cardiovascular disease-free adults.

Methods
The ATTICA study is a cross-sectional population-based survey that
conducted in Attica region during 2001-2002. Based on a multistage and
stratified random sampling, 1514 men and 1528 women (18-89 years old)
were enrolled. The survey included a detailed interview; blood samples
collected after 12h of fasting and, among other clinical measurements,
status of blood pressure levels was evaluated.

Results
Six hundred and fifty-three men (43%) and 535 women (35%) were defined
as pre-hypertensives. Both systolic and diastolic blood pressures were
inversely correlated with TAC (p<0.001) and positively correlated to
oxidized LDL (p<0.001). Particularly, compared to normotensive
subjects, pre-hypertensives had 7% lower TAC levels (p<0.001) and 15%
higher oxidized LDL levels (p<0.05), after correcting for multiple
comparisons and adjusting for age, body mass index, blood lipids,
glucose, food groups consumed and other potential confounders.

Conclusions
Studying a large sample of cardiovascular disease-free adults, we
revealed an association of pre-hypertension with oxidative stress
markers linking to atherosclerotic process.

Marilyn

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