Statin Myopathy - Cmax or AUC

I have developed myopathy on just about every statin except Lescol,
the statin of last resort, according to Jay Cohen's book. So next
visit I will ask my doctor about giving Lescol a try.

In checking out Lescol, I discovered they have regular 20, 40 & 80 mg
capsules plus an 80 mg controlled release tablet. So my first thought
was try the 20 mg - it should have minimum potential for causing
myopathy. But in looking over the Lescol data I spotted two variables
of interest. First is C sub max, the maximum plasma concentration of
fluvastatin. Second is AUC, the area under the concentration versus
time curve.

With 20 mg dose C sub max is ~170 and AUC ~200
With 80 mg extended release C sub max is ~100 and AUC ~650

AUC should theoretically correlate with cholesterol reduction.

Question is which variable should best correlate myopathy? There is
no consensus on the cause of myopathy so I am fairly sure there are no
correlations. Any speculations, other than Lescol will be like all the
other statins and I'm screwed.
.

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