Re: Is the diet heart hypothesis really still alive.

On 29 Apr, 19:36, "Juhana Harju" <n...@xxxxxxx> wrote:
tonyzs...@xxxxxxxxx wrote:

: I have recently been reading The Colesterol Myths in which Dr Uffe
: Ravnskov sets out to demonstrate that thediet-hearthypothesisis not
: sustainable. He supports his conclusions with a meticulous analysis
: of a large number of cited studies and reviews. His demolition of the
: Seven Countries Study is, to my mind, totally credible.
:
: Although Dr Ravnskov seems to have covered everything of importance on
: this vast subject I am wondering whether there are any studies or
: reviews (major or otherwise) that can convincingly demonstrate the
: following:
:
: (1) that high fat diets are associated with high levels of blood
: cholesterol.

The quality of dietary fats is important, not the amount.

: (2) that high levels of blood cholesterol are associated with high
: levels of CHD.

Ravnskov often speaks about cholesterol (meaning serum total cholesterol).
That is outdated as total cholesterol is not a very good predictor ofheart
disease. Cholesterol ratios (total cholesterol to HDL) should be used
instead. Triglyserides are also important particularly in overweight people.

: Without this evidence thehypothesisis dead. I should say that I am
: not seeking to be controversial but write as an elderly non scientist
: withheartproblems, who genuinely wants to know what the score is.

Take a look at LyonDietHeartTrial. That is a study where a modificated
Mediterraneandietwas compared with adietrecommended by AmericanHeart
Association. Patients following the Mediterraneandiethad *70 percent*
reducedheartdisease and total mortality. In the Mediterraneandietthe
subjects were adviced to replace saturated fats with olive oil, canola oil
and with a rape seed oil based margarine. They were suggested to do some
otherdietchanges as well. The subjects in the Mediterraneandietgroup
were observed to have higher levels of omega-3 fatty acids, more oleic acid
and higher levels of antioxidants than subjects in the control group.

I don't think that thediethearthypothesisis dead, quite the contrary.
The evidence is accumulating. Increase the intake of omega-3 fatty acids.
Use cold pressed and virgin vegetable oils - olive oil and canola/rape seed
oil are good choices. Cut the refined carbohydrates. Avoid trans fats very
strictly. Cut saturated fats. Eat some whole grains. Favour fatty fish and
vegetarian protein sources. Eat less red meat. Do not forget nuts. Eat more
vegetables, fruits and berries. Green vegetables are important. Pomegranates
are terrific.

--
Juhana

Thank you Juhana for drawing my attention to the Lyon study. I did
post a reply to you but my lack of cyber competence seems to have sent
it out of sight. Sorry for that. However the 70% reduction that is
generally accepted is a pretyy compelling argument in favour of the
diet hear hypothesis. I had difficulty, however, in locating the
figure for actual deaths and actual cardiac events: different figures
are quoted in different abstracts. One set of figures for cardiac
deaths and myodcardial infarctions in the treatment group is 14, and
inm the control group:44. I take this to be the basis for the quoted
70% reduction ( relative terms). In absolute terms the difference is
9% (13.1%-4.1%) - not nearly so impressive as 70%, but neverhteless
impressive. I shall be doing some further digging about on this
subject but you may wish to comment on:

(1) are there any other studies that replicate and confirm the
findings of the Lyon study.

(2) If the findings of the Lyon study are so compelling how did
statins ever achieve the degree of medical consensus that they have at
the moment?

Tony.

.

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