Re: Consumption of Fructose-, but not Glucose-Sweetened Beverages Produces an Atherogenic Lipid Profile in Overweight/Obese Men and Women

MarilynMann wrote:
Abstract from the American Diabetes Association Scientific Sessions:

Authors: Kimber Stanhope et al.

Results:
Consumption of sugar-sweetened beverages containing fructose has
increased by 135% from 1977 to 2001 and may be a contributing factor
to an increased incidence of metabolic syndrome. Direct experimental
evidence that fructose consumption promotes the metabolic syndrome in
humans is lacking. We investigated the effects of 10 weeks of
fructose compared with glucose consumption on lipid parameters in
overweight/obese (BMI: 25-35 kg/m2) adults. Subjects resided in the
Clinical and Translational Science Research Center (CCRC) for 2
weeks. Baseline procedures, including a 24-hr blood collection, were
conducted while subjects consumed an energy-balanced, moderate fat
(30%), high complex carbohydrate (55%) diet. Subjects then began an 8-
week outpatient intervention and consumed either fructose- (n=13) or
glucose-sweetened (n=10) beverages at 25% of energy requirements with
a self-selected ad libitum diet. At 2, 8, & 10 weeks of intervention,
additional 24-hr blood collections were performed. At intervention
week 9, subjects returned to the CCRC for 2 weeks while consuming the
beverages with the energy balanced diet. 24 hr postprandial
triglyceride (TG) profiles were increased by 212 +-59% after 2 weeks
of fructose consumption (p<0.0001), but tended to decrease (-30 +-23%)
in subjects consuming glucose. Fasting plasma concentrations of LDL-C
(+17 +-4%), apoB (+28 +-7%), small dense (sd) LDL-C (+27 +-11%), &
postprandial concentrations of remnant lipoprotein (RLP)-TG (+77
+-19%) and of RLP-cholesterol (+53 +-12%) were increased (p<0.01) in
subjects consuming fructose-sweetened beverages, but were unchanged in
those consuming glucose beverages. These changes were maintained
after 8 & 10 weeks of fructose consumption. In addition, plasma
concentrations of oxidized LDL-C were increased by 15 +-2% (p<0.0001)
and intracellular adhesion molecule (ICAM) increased by 8 +-3%
(p<0.05) in subjects consuming fructose, but not in those consuming
glucose. Increased postprandial TGs, LDL-C, apoB, sdLDL-C, RLPs,
oxidized LDL, and sICAM are considered risk factors for
atherosclerotic cardiovascular disease. Thus, consumption of 25% of
energy requirements from fructose promotes an atherogenic lipid
profile within 2 weeks, whereas consuming 25% of energy from glucose
does not. Persons at risk for developing metabolic syndrome and
cardiovascular disease should avoid overconsumption of fructose-
containing beverages.

* * *

Most beverages are either fructose (corn syrup) or sucrose (cane
sugar) sweetened because glucose is actually not very sweet. Fructose
is also the sugar in fruits.

It would be wise for obese folks not only to avoid corn syrup
sweeteners but also fruits.

May GOD bless you in HIS mighty way making you healthier (hungrier)
than ever.

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist

.

Relevant Pages