Re: Effect of the Magnitude of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer: Insights From Large Randomized Statin Trials

On Jul 26, 8:34 pm, James216...@xxxxxxxxx wrote:
On 25 Jul, 12:51, Jim Chinnis <jchin...@xxxxxxxxxxxxxxxx> wrote:

MarilynMann <ma...@xxxxxxxxxxx> wrote in part:

New analysis uncovers relationship between low LDL-cholesterol levels
and cancer
expect to start to see cancers resulting from statin treatment.

A very big hint in the pretty weak data package is cancers seen were
not specific. Virtually all chemical carcinogens strongly target
particular organs rather then cause a non specific distribution of
cancers.

In plain English these people were going to get cancer regardless of
treatment.

Unfortunately the latest study finds a significant link
"
Conclusions: Risk of statin-associated elevated liver enzymes or
rhabdomyolysis is not related to the magnitude of LDL-C lowering.
However, the risk of cancer is significantly associated with lower
achieved LDL-C levels. These findings suggest that drug- and dose-
specific effects are more important determinants of liver and muscle
toxicity than magnitude of LDL-C lowering. Furthermore, the
cardiovascular benefits of low achieved levels of LDL-C may in part
be
offset by an increased risk of cancer. http://content.onlinejacc.org/cgi/content/short/50/5/409

Sometimes the science seems to get in the way.
Thanks Vince


.

Relevant Pages

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