Are statins effective for simultaneously treating dyslipidemias and hypertension?
- From: MarilynMann <mannm@xxxxxxxxxxx>
- Date: Sun, 29 Jul 2007 15:53:31 -0700
Are statins effective for simultaneously treating dyslipidemias and
hypertension?
Kwang Kon Koha, , , Michael J. Quonb and Myron A. Waclawiwc
aVascular Medicine and Atherosclerosis Unit, Division of Cardiology,
Gachon University, Gil Medical Center, 1198 Kuwol-dong, Namdong-gu,
Incheon 405-760, South Korea
bDiabetes Unit, Laboratory of Clinical Investigation, NCCAM, National
Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA
cOffice of Biostatistics Research, National Heart, Lung, and Blood
Institute, NIH, Bethesda, MD, USA
Atherosclerosis, Received 3 May 2007; revised 14 June 2007; accepted
17 June 2007. Available online 26 July 2007.
Abstract
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
(statins) are unequivocally useful for lowering cholesterol levels in
patients with dyslipidemias characterized by elevations in total and/
or low-density lipoprotein cholesterol. The beneficial effects of
statins to lower serum cholesterol translate into significant
reductions in cardiovascular morbidity and mortality. In addition to
lowering cholesterol levels, statins have other biological effects
relevant to cardiovascular homeostasis including anti-inflammatory
actions and downregulation of angiotensin type 1 receptor expression
that contribute to improvements in enodthelial function and arterial
compliance. Since enodthelial dysfunction and reduced arterial
compliance are important pathophysiological determinants of essential
hypertension, these actions of statins raise the possibility that
statin therapy may be useful for simultaneously treating dyslipidemias
and hypertension. However, it has been unclear whether statins are
effective in lowering blood pressure. This controversy stems from a
variety of methodological limitations including inadequate sample
size, confounding effects of antihypertensive drugs, differences in
blood pressure measurement techniques, and differences in patient
populations. However, based on published results from both small
clinical studies and large randomized clinical trials, statins
modestly lower blood pressure in patients with high, but not normal,
blood pressure, regardless of cholesterol level.
Corresponding author. Tel.: +82 32 460 3683; fax: +82 32 460 3117.
Marilyn
.
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