Re: Effect of the Magnitude of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer: Insights From Large Randomized Statin Trials

On Jul 27, 10:48 pm, James216...@xxxxxxxxx wrote:


Science is not in the way at all. Significantly associated does not
in any way either suggest causation nor even say that the increase in
cancer rate is statistically significant, which it is not.

It certainly does not show that statins do not increase the risk of
cancer. From the study

Conclusions: Risk of statin-associated elevated liver enzymes or
rhabdomyolysis is not related to the magnitude of LDL-C lowering.
However, the risk of cancer is significantly associated with lower
achieved LDL-C levels. These findings suggest that drug- and dose-
specific effects are more important determinants of liver and muscle
toxicity than magnitude of LDL-C lowering. Furthermore, the
cardiovascular benefits of low achieved levels of LDL-C may in part
be
offset by an increased risk of cancer. '

These authors suggest that statin use may indeed increase the risk of
cancer.

For example there is a strong correlation between fatal heart attack
rates and total tax rates in the country of occupancy. Are you going
to try to tell me politicians cause heart attacks?

This does not seem particularly relevant

Only someone who knows very little about cancer and latency would even
consider looking at such short term studies as any indication at all
of causation. Even hot carcinogens do not act this fast unless the
dose is out of sight. We all know that statins are not hot
carcinogens by any means.

Actually this reasoning argues against the original studies that
cleared statins as a group of causing cancer.Some individually studies
however showed higher cancer rates for some statins.by your on logic
the earlier studies would have had to short a time to show increase
rates of cancer.In fact any such correlation based on low dose statin
use would argue against higher doses because dose is indeed a key in
this regard..


This study does not" prove "statins cause cancer it also certainly
raises serious question about previous studies showing they do not,

Thanks Vince

.

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