Re: HYVET stopped early

On Aug 9, 4:47 pm, Jim Chinnis <jchin...@xxxxxxxxxxxxxxxx> wrote:
bigvince <Vince.Mirag...@xxxxxxxxx> wrote in part:





On Aug 9, 12:30 pm, Jim Chinnis <jchin...@xxxxxxxxxxxxxxxx> wrote:

A major reason that hypertension is dangerous is because of its chronic
effects on the endothelium, on heart muscle, and other tissues/systems that
are affected by the sympathetic nervous system. You are trying to regard
"used for hypertension" as hypertension in the absence of atherosclerosis or
ischemic heart disease. Those are common companions of hypertension.

There are a number of papers in Medline that detail benefits of atenolol in
improved heart remodelling and improved response of the endothelium etc. to
stress.

Heres a very new look at that issue from

J Am Coll Cardiol, 2007; 50:563-572, doi:10.1016/j.jacc.
2007.04.060 (Published online 29 July 2007).
STATE-OF-THE-ART PAPER
Cardiovascular Protection Using Beta-Blockers
A Critical Review of the Evidence

The review of the currently available literature shows that in
patients with uncomplicated hypertension, there is a paucity of data
or absence of evidence to support use of beta-blockers as monotherapy
or as first-line agents. Given the increased risk of stroke, their
"pseudo-antihypertensive" efficacy (failure to lower central aortic
pressure), lack of effect on regression of target end organ effects
like left ventricular hypertrophy and endothelial dysfunction, and
numerous adverse effects, the risk benefit ratio for beta-blockers is
not acceptable for this indication.'

Jim it seems this study noted the lack of effect on LVH
remodelling,AND endothelial dysfunction.

Thanks Vince

I don't really disagree with the paragraph above from JACC. But it still
relates to monotherapy and "uncomplicated" hypertension. The benefits I've
seen that relate to the endothelium are in its response to stress.
--
Jim Chinnis Warrenton, Virginia, USA- Hide quoted text -

- Show quoted text -

All my comments have related to uncomplicated hypertension as far as
combination treatment theres the Ascot trails where the combination of
atenolol and a diuretic was compared againt the combination of CCB and
ACE inhibitor . Result stoped early because of difference in mortality
rates favoring ACE inhibitor arm. There the LIFE study atenolol
v Losartan diurectic added to each as needed. More strokes atenolol
arm.

Thanks Vince

.

Relevant Pages

  • Re: HYVET stopped early
    ... A major reason that hypertension is dangerous is because of its chronic ... ischemic heart disease. ... improved heart remodelling and improved response of the endothelium etc. to ... Cardiovascular Protection Using Beta-Blockers ...
    (sci.med.cardiology)
  • Re: HYVET stopped early
    ... A major reason that hypertension is dangerous is because of its chronic ... ischemic heart disease. ... improved heart remodelling and improved response of the endothelium etc. to ... Cardiovascular Protection Using Beta-Blockers ...
    (sci.med.cardiology)
  • Re: Should I be taking Atenolol as first treatment for HBP (42 year old WM) ???
    ... Dr.Lindholm explains that all studies including atenolol are included ... hypertension speacialist he is more vocal about this drug. ... Beta blockers as a class are useful in the ...
    (sci.med.cardiology)
  • Re: atenolol and insulin resistance
    ... Hemodynamic and metabolic responses to valsartan and atenolol in obese ... None of the current hypertension guidelines provides ... Treatment recommendations for lean ... PATIENTS: Obese patients with mild to moderate uncomplicated essential ...
    (sci.med.cardiology)
  • Re: blood pressure pill nightmare
    ... Reducing heart rate in hypertension is harmful?or is it just atenolol? ... with beta blockers post-MI and in heart failure, ...
    (sci.med.cardiology)