Re: Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: The Tromsø study

Endogenous testosterone and endothelial function in postmenopausal
women.

Coronary Artery Disease. 18(1):9-13, February 2007.

Montalcini, Tiziana; Gorgone, Gaetano; Gazzaruso, Carmine; Sesti,
Giorgio; Perticone, Francesco; Pujia, Arturo

Abstract:
Objective: It is well known that coronary heart disease incidence
increases in women after menopause. This phenomenon was related to
reduced levels of female sex hormones. Estrogen decline, however, is
not the only hormonal change during the postmenopausal period and
estrogen administration did not protect women from cardiovascular
disease. Therefore, it is justified to explore other hormonal changes.
The role of androgens is still controversial. The aim of the present
study was to investigate the relationship between endogenous sex
hormones and endothelial function, measuring the brachial artery flow-
mediated dilation.

Methods and results: Sixty postmenopausal women were consecutively
enrolled and underwent a clinical and biochemical examination.
Brachial artery flow-mediated dilation was also evaluated by
ultrasound. After correction for confounding variables, testosterone
was positively correlated to flow-mediated dilation ([beta]=0.277,
P=0.03). Indeed, women in the lowest testosterone tertile had a flow-
mediated dilation smaller than that in the highest tertile (P=0.02).

Conclusions: This result could suggest that the development of
cardiovascular disease after menopause is due not only to estrogen
decline but also to androgen decline. More studies are needed to
evaluate the role of androgen replacement therapy on postmenopausal
women with low level of this hormone.



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