Re: Do drugs {including statins} and procedures benefit women and men equally?

On Sep 9, 12:54 pm, Jim Chinnis <jchin...@xxxxxxxxxxxxxxxx> wrote:


Bottom line to me is that the HPS study *suggests* that equally at risk
women would benefit much the same as men. It certainly does not support your
statement that statins have even less value for women than for men. Even if
you ignore the difference in risk levels between the men and women included,
the women still exhibit a sizable effect close to that of the men. If you
want to insist that we ignore the data completely unless each post-hoc
subgroup comparison achieves p<0.05, there is so support whatsoever for your
statement that statins have even less value for women than for men. For
that, you need a p<0.05 result showing that women's benefit is *less* than
that for men. You sure don't have that here in this largest of all the
controlled trials on statins.

1- Jim my comments where in reference to all statins many studies
have shown no benefit in primary prevention for any one male or female
some studies have show differences the way men and women react to
statin use.No study not even the HPS shows significant mortality
benefit in women in . The 4s study which you have been going to
address actually has more women dieing in the treatment arm.
Statistical games can not change the fact that no significant
mortality effects have ever been seen in women . from the Jacc
article
What about extrapolations to women?

To date, there is no evidence for a total mortality benefit in women
from dyslipidemia therapy. Two of three trials that have released data
on gender-specific total mortality with lipid therapy (6,10) have
actually shown increases in the treatment group of 57% and 12%,
respectively, whereas the third reported a 1% decrease (11). None of
these differences was individually statistically significant. The
studies where Tex Caps ; 4s and Lipid : source
Low and lowered cholesterol and total mortality*
Michael H. Criqui, MD, MPH,,* and Beatrice A. Golomb, MD, PhD,

Perhaps we can discuss Tex Caps or more relevantly 4s where the same
statin produced different results.

The best that can be said about the HPS study it can not prove
mortality benefit in women even in secondary prevention

2. Statins work by lipid lowering and other modes the only way to know
what "statins do" is to run outcome based test not to use an surrogate
marker like lipids when these drugs may have very different effects
while reducing lipids an eqaul .amount.TC levels are not related to
risk in women , and tend to be protective in the elderly the only
group where TC levels our slightly associated with risk is middle aged
men that fact alone should cause us to suspect different outcomes as a
result of lipid lowering.

3. The only way to know what statins do is the meta analysis several
have been done they all conclude
something like this ... ' Conclusions For women without
cardiovascular disease, lipid lowering does not affect total or CHD
mortality. Lipid lowering may reduce CHD events, but current evidence
is insufficient to determine this conclusively. For women with known
cardiovascular disease, treatment of hyperlipidemia is effective in
reducing CHD events, CHD mortality, nonfatal myocardial infarction,
and revascularization, but it does not affect total mortality.
"...Drug Treatment of Hyperlipidemia in Women
Judith M. E. Walsh, MD, MPH; Michael Pignone, MD, MPH

JAMA. 2004;291:2243-2252. To talk about statin effects and use one
study is not logical . Even the effect of the HPS in regards to women
has to be suspect because of the difference in effect in the 4s study
on the sanme statin.

4.More studys on statins source http://www.westonaprice.org/tour/index.html

J-LIT (2002)
Japanese Lipid Intervention Trial was a 6-year study of 47,294
patients treated with the same dose of simvastatin.43 Patients were
grouped by the amount of cholesterol lowering. Some patient had no
reduction in LDL levels, some had a moderate fall in LDL and some had
very large LDL reductions. The results: no correlation between the
amount of LDL lowering and death rate at five years. Those with LDL
cholesterol lower than 80 had a death rate of just over 3.5 at five
years; those whose LDL was over 200 had a death rate of just over 3.5
at five years.

ASCOT-LLA (2003)
ASCOT-LLA (Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering
Arm) was designed to assess the benefits of atorvastatin (Lipitor)
versus a placebo in patients who had high blood pressure with average
or lower-than-average cholesterol concentrations and at least three
other cardiovascular risk factors.48 The trial was originally planned
for five years but was stopped after a median follow-up of 3.3 years
because of a significant reduction in cardiac events. Lipitor did
reduce total myocardial infarction and total stroke; however, total
mortality was not significantly reduced. In fact, women were worse off
with treatment. The trial report stated that total serious adverse
events "did not differ between
patients assigned atorvastatin or placebo," but did not supply the
actual numbers of serious events.

A television ad in Canada admonished viewers to "Ask your doctor about
the Heart Protection Study from Oxford University." The ad did not
urge viewers to ask their doctors about EXCEL, ALLHAT, ASCOT, MIRACL
or PROSPER, studies that showed no benefit--and the potential for
great harm--from taking statin drugs.


Thanks Vince

.

Relevant Pages

  • Re: Do drugs {including statins} and procedures benefit women and men equally?
    ... Bottom line to me is that the HPS study *suggests* that equally at risk ... statement that statins have even less value for women than for men. ... mortality effects have ever been seen in women. ... on gender-specific total mortality with lipid therapy have ...
    (sci.med.cardiology)
  • Re: Fish oils plus statins help protect heart (Article reprint)
    ... ::: those taking statins. ... :: The question how much reduction statins provide in those who are ... the risk of CHD 33% compared with patients randomized to diet alone. ... Effect of Different Antilipidemic Agents and Diets on Mortality ...
    (sci.med.cardiology)
  • Re: Bad LDL cholesterol may benefit elderly
    ... > I supplied over THIRTY TWO references regarding adverse effects outweighing ... > any benefits of statins for elderly, ... >>> cardiovascular disease receive mortality benefit from statins in studies ... >>> at high risk for cardiovascular disease ...
    (sci.med.cardiology)
  • Re: Bad LDL cholesterol may benefit elderly
    ... >>>We have large randomized trials showing that statins decrease mortality ... While patients at high risk for cardiovascular disease ...
    (sci.med.cardiology)
  • Re: another one for the Aussie posters
    ... Gaps between guideline recommendations and practice in ... When stratified by absolute risk, patients at high risk of a ... at least as far as prescribing statins goes. ... Highly unlikely since normalisation of the lipid profile is the most ...
    (alt.support.diabetes)
Loading