Re: Ping JWN
From: Jan (jdrew63929_at_aol.com)
Date: 08/11/04
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Date: 11 Aug 2004 05:21:14 GMT
>Subject: Re: Ping JWN
>From: "JWN DDS" bob@bob.com
>Date: 8/10/2004 8:21 PM Pacific Standard Time
>Message-id: <l9hSc.72504$gE.51454@pd7tw3no>
>
>Answer what?
You read it. Answer it.
<snip insults>
http://tinyurl.com/3bp8f
1: Adv Dent Res. 1992 Sep;6:110-3. Related Articles, Links
Side-effects: mercury contribution to body burden from dental amalgam.
Reinhardt JW.
Department of Operative Dentistry, University of Iowa College of Dentistry,
Iowa City 52242.
The purpose of this paper is to examine and report on studies that relate
mercury levels in human tissues to the presence of dental amalgams, giving
special attention to autopsy studies. Until recently, there have been few
published studies examining the relationship between dental amalgams and tissue
mercury levels. Improved and highly sensitive tissue analysis techniques have
made it possible to measure elements in the concentration range of parts per
billion. The fact that mercury can be absorbed and reach toxic levels in human
tissues makes any and all exposure to that element of scientific interest.
Dental amalgams have long been believed to be of little significance as
contributors to the overall body burden of mercury, because the elemental form
of mercury is rapidly consumed in the setting reaction of the restoration.
Studies showing measurable elemental mercury vapor release from dental amalgams
have raised renewed concern about amalgam safety. Mercury vapor absorption
occurs through the lungs, with about 80% of the inhaled vapor being absorbed by
the lungs and rapidly entering the bloodstream. Following distribution by blood
circulation, mercury can enter and remain in certain tissues for longer periods
of time, since the half-life of excretion is prolonged. Two of the primary
target organs of concern are the central nervous system and kidneys.
Publication Types:
Review
Review, Tutorial
PMID: 1292449 [PubMed - indexed for MEDLINE]
http://tinyurl.com/2ld6k
J Alzheimers Dis. 2003 Jun;5(3):189-95. Related Articles, Links
Apolipoprotein E genotyping as a potential biomarker for mercury neurotoxicity.
Godfrey ME, Wojcik DP, Krone CA.
Bay of Plenty Environmental Health Clinic, Tauranga, New Zealand.
godfrey@wave.co.nz
Apolipoprotein-E (apo-E) genotyping has been investigated as an indicator of
susceptibility to heavy metal (i.e., lead) neurotoxicity. Moreover, the apo-E
epsilon (epsilon)4 allele is a major risk factor for neurodegenerative
conditions, including Alzheimer's disease (AD). A theoretical biochemical basis
for this risk factor is discussed herein, supported by data from 400 patients
with presumptive mercury-related neuro-psychiatric symptoms and in whom apo-E
determinations were made. A statistically relevant shift toward the at-risk
apo-E epsilon4 groups was found in the patients p<0.001). The patients
possessed a mean of 13.7 dental amalgam fillings and 31.5 amalgam surfaces.
This far exceeds the number capable of producing the maximum identified
tolerable daily intake of mercury from amalgam. The clinical diagnosis and
proof of chronic low-level mercury toxicity has been difficult due to the
non-specific nature of the symptoms and signs. Dental amalgam is the greatest
source of mercury in the general population and brain, blood and urine mercury
levels increase correspondingly with the number of amalgams and amalgam
surfaces in the mouth. Confirmation of an elevated body burden of mercury can
be made by measuring urinary mercury, after provocation with
2,3,-dimercapto-propane sulfonate (DMPS) and this was measured in 150 patients.
Apo-E genotyping warrants investigation as a clinically useful biomarker for
those at increased risk of neuropathology, including AD, when subjected to
long-term mercury exposures. Additionally, when clinical findings suggest
adverse effects of chronic mercury exposure, a DMPS urine mercury challenge
appears to be a simple, inexpensive procedure that provides objective
confirmatory evidence. An opportunity could now exist for primary health
practitioners to help identify those at greater risk and possibly forestall
subsequent neurological deterioration.
PMID: 12897404 [PubMed - indexed for MEDLINE]
http://tinyurl.com/2h6y4
Altern Med Rev. 2000 Jun;5(3):209-23. Related Articles, Links
Environmental medicine, part three: long-term effects of chronic low-dose
mercury exposure.
Crinnion WJ.
Healing Naturally, 11811 NE 128th St., Suite 202, Kirkland, WA 98034, USA.
Mercury is ubiquitous in the environment, and in our mouths in the form of
"silver" amalgams. Once introduced to the body through food or vapor, mercury
is rapidly absorbed and accumulates in several tissues, leading to increased
oxidative damage, mitochondrial dysfunction, and cell death. Mercury primarily
affects neurological tissue, resulting in numerous neurological symptoms, and
also affects the kidneys and the immune system. It causes increased production
of free radicals and decreases the availability of antioxidants. It also has
devastating effects on the glutathione content of the body, giving rise to the
possibility of increased retention of other environmental toxins. Fortunately,
effective tests are available to help distinguish those individuals who are
excessively burdened with mercury, and to monitor them during treatment.
Therapies for assisting the reduction of a mercury load include the use of
2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercato-1-propanesulfonic acid
(DMPS). Additional supplementation to assist in the removal of mercury and to
reduce its adverse effects is discussed.
Publication Types:
Review
Review, Tutorial
PMID: 10869102 [PubMed - indexed for MEDLINE]
http://tinyurl.com/2gnwl
: Br Dent J. 1997 May 24;182(10):373-81. Related Articles, Links
The future of dental amalgam: a review of the literature. Part 4: Mercury
exposure hazards and risk assessment.
Eley BM.
Periodontal Department, King's College School of Medicine & Dentistry, London.
This is the fourth article in a series of seven on the future of dental
amalgam. It first describes toxic mercury hazards from all sources of exposure
including dental amalgam. It begins by considering the many problems in
accurately estimating daily mercury intakes from these sources. It then
describes potential mercury hazards to industrial workers and the calculation
of thresholds for the general public from industrial data. The implications of
these findings to the production of a safe threshold for patients with dental
amalgams are then discussed. It finally discusses the attempts which have been
made to carry out a risk assessment of dental amalgam. In this connection it
reports the reviews of the United States Public Health Service in 1993, the
Swedish National Board of Health and Welfare in 1994 and the risk assessment
commissioned from Canada Health which was reported in 1995. It also includes
comments on the methods used in this last report.
Publication Types:
Review
Review, Tutorial
PMID: 9185355 [PubMed - indexed for MEDLINE]
http://tinyurl.com/yuj39
Acupunct Electrother Res. 1996 Apr-Jun;21(2):133-60. Related Articles, Links
Significant mercury deposits in internal organs following the removal of dental
amalgam, & development of pre-cancer on the gingiva and the sides of the tongue
and their represented organs as a result of inadvertent exposure to strong
curing light (used to solidify synthetic dental filling material) & effective
treatment: a clinical case report, along with organ representation areas for
each tooth.
http://tinyurl.com/2gnwl
1: Br J Dermatol. 1996 Mar;134(3):420-3. Related Articles, Links
The relevance and effect of amalgam replacement in subjects with oral lichenoid
reactions.
Ibbotson SH, Speight EL, Macleod RI, Smart ER, Lawrence CM.
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
In this study we examined the prevalence of mercury hypersensitivity in
patients with oral lichenoid reactions (OLR) and the effect of amalgam
replacement in subjects with amalgams adjacent to OLR irrespective of their
mercury sensitivity status. One hundred and ninety-seven patients with oral
problems were examined: 109 with OLR, 22 with oral and generalized lichen
planus, and 66 with other oral diagnoses, including aphthous ulcers and
orofacial granulomatosis. Nineteen per cent of patients with OLR reacted to
mercury on patch testing, significantly more than in those with generalized
lichen planus (0%) and in those with other oral diagnoses (3%). Twenty-two
patients with OLR and adjacent amalgams had amalgam replacement and, in 16 of
17 mercury-positive subjects and three of four mercury-negative subjects, the
OLR resolved after amalgam removal. In conclusion, we found a significantly
increased prevalence of mercury hypersensitivity in patients with localized OLR
in comparison to subjects with other oral problems. Amalgam replacement
resulted in resolution of OLR in the majority of patients with amalgams
adjacent to OLR irrespective of their mercury sensitivity status.
PMID: 8731663 [PubMed - indexed for MEDLINE]
http://tinyurl.com/2dp6g
1: Psychol Rep. 1992 Jun;70(3 Pt 2):1139-51. Related Articles, Links
A comparison of mental health of multiple sclerosis patients with
silver/mercury dental fillings and those with fillings removed.
Siblerud RL.
Rocky Mountain Research Institute, Inc., Colorado.
In this study was compared the mental health status of 47 multiple sclerosis
patients with silver/mercury tooth fillings (amalgams) to that of 50 patients
with their fillings removed. On the Beck Depression Inventory the multiple
sclerosis subjects with amalgams suffered significantly more depression while
their scores on the State-Trait Anger Expression Inventory indicated the former
group also exhibited significantly more anger. On the SCL-90 Revised, subjects
with amalgam fillings had significantly more symptoms of depression, hostility,
psychotism, and were more obsessive-compulsive than the patients with such
fillings removed. On a questionnaire containing 18 mental health symptoms
multiple sclerosis subjects with amalgam fillings reported a history of 43%
more symptoms than those without amalgam fillings over the past 12 months.
These data suggested that the poorer mental health status exhibited by multiple
sclerosis subjects with dental amalgam fillings may be associated with mercury
toxicity from the amalgam.
PMID: 1496084 [PubMed - indexed for MEDLINE]
http://tinyurl.com/2ukse
: Am J Psychother. 1989 Oct;43(4):575-87. Related Articles, Links
The relationship between mercury from dental amalgam and mental health.
Siblerud RL.
Colorado State University, Department of Physiology, Fort Collins.
The findings presented here suggest that mercury poisoning from dental amalgam
may play a role in the etiology of mental illness. Comparisons between subjects
with and without amalgam showed significant differences in subjective reports
of mental health. Subjects who had amalgams removed reported that symptoms of
mental illness lessened or disappeared after removal. The data suggest that
inorganic mercury poisoning from dental amalgam does affect the mind and
emotions.
PMID: 2618948 [PubMed - indexed for MEDLINE]
polipoprotein-E (apo-E) genotyping has been investigated as an
indicator of susceptibility to heavy metal (i.e., lead) neurotoxicity.
Moreover, the apo-E epsilon ( varepsilon )4 allele is a major risk
factor for neurodegenerative conditions, including Alzheimer's disease
(AD). A theoretical biochemical basis for this risk factor is discussed
herein, supported by data from 400 patients with presumptive mercury
-related neuro-psychiatric symptoms and in whom apo-E
determinations were made. A statistically relevant shift toward the
at-risk apo-E varepsilon 4 groups was found in the patients p<0.001).
The patients possessed a mean of 13.7 dental amalgam fillings and 31.5
amalgam surfaces. This far exceeds the number capable of producing
the maximum identified tolerable daily intake of mercury from amalgam.
The clinical diagnosis and proof of chronic low-level mercury toxicity
has been difficult due to the non-specific nature of the symptoms and
signs. Dental amalgam is the greatest source of mercury in the general
population and brain, blood and urine mercury levels increase
correspondingly with the number of amalgams and amalgam surfaces
in the mouth. Confirmation of an elevated body burden of mercury
can be made by measuring urinary mercury, after provocation with
2,3,-dimercapto-propane sulfonate (DMPS) and this was measured
in 150 patients. Apo-E genotyping warrants investigation as a
clinically useful biomarker for those at increased risk of
neuropathology, including AD, when subjected to long-term mercury
exposures. Additionally, when clinical findings suggest adverse
effects of chronic mercury exposure, a DMPS urine mercury
challenge appears to be a simple, inexpensive procedure that
provides objective confirmatory evidence. An opportunity could now
exist for primary health practitioners to help identify those at greater
risk and possibly forestall subsequent neurological deterioration.
PMID: 12897404 [PubMed - in process]
JWN - please explain the following statements and enlighten me - I
thought you said amalgam was definitely safe?! Why are all these
scientists wasting society's valuable resources continuing to investigate
this "non-issue" ? (sarcasm intended)
"The patients possessed a mean of 13.7 dental amalgam fillings and
31.5 amalgam surfaces. This far exceeds the number capable of
producing the maximum identified tolerable daily intake of mercury
from amalgam"
"An opportunity could now exist for primary health practitioners to
help identify those at greater risk and possibly forestall subsequent
neurological deterioration."
= = = = = = =
Some medical practitioners prescribe GSH and vitamin C alone or in
combination with DMPS or DMSA for patients with mercury
exposure that is primarily due to the mercury vapor emitted by dental
amalgams. HYPOTHESIS: This study tested the hypothesis that
GSH, vitamin C, or lipoic acid alone or in combination with DMPS or
DMSA would decrease brain mercury. METHODS: Young rats were
exposed to elemental mercury by individual nose cone, at the rate of
4.0 mg mercury per m3 air for 2 h per day for 7 consecutive days.
After a 7-day equilibrium period, DMPS, DMSA, GSH, vitamin C,
lipoic acid alone, or in combination was administered for 7 days and
the brain and kidneys of the animals removed and analyzed for
mercury by cold vapor atomic absorption. RESULTS: None of these
regimens reduced the mercury content of the brain. Although DMPS
or DMSA was effective in reducing kidney mercury concentrations,
GSH, vitamin C, lipoic acid alone, or in combination were not.
CONCLUSION: One must conclude that the palliative effect, if any,
of GSH, vitamin C, or lipoic acid for treatment of mercury toxicity
due to mercury vapor exposure does not involve mercury
mobilization from the brain and kidney. PMID: 12870874
[PubMed - indexed for MEDLINE]
JWN - please explain the following statements and enlighten me - I
thought you said amalgam was definitely safe?! Why are all these
scientists wasting society's valuable resources continuing to investigate
this "non-issue" ? (sarcasm intended)
"...mercury exposure that is primarily due to the mercury vapor emitted
by dental amalgams"
"...for treatment of mercury toxicity due to mercury vapor exposure..."
= = = = = = =
AIMS: This paper reviews the studies, both in vivo and in vitro,
carried out for the project on low-dose effects of inorganic mercury,
financed by the Italian Ministry of Universities and Scientific and
Technological Research. RESULTS, COMMENTS AND
PROPOSAL: The results offer both innovative aspects and potential
practical applications. Particular attention is drawn to the reliability
of biomarkers of exposure [mercury in urine (HgU) and blood (HgB),
possibility of speciation] as well as to the availability of guidance
values for risk assessment (reference value, action level, biological
threshold value). In the general population, HgU and HgB levels are
significantly related to the presence of dental amalgams and to fish
consumption; nevertheless, such exposure levels do not elicit adverse
health effects on renal, immune and nervous functions, according to
the markers evaluated in the studies. The present biological threshold
values for occupational exposure appear adequate to prevent health
effects, considering the immune system, kidney and central nervous
system as the target organs. However, possible effects of low doses
of mercury on immune and neuroendocrine functions should be
further examined; moreover, consideration should be given to the risk
of consuming fish species with high Hg content, particularly
concerning the renal and central nervous system effects. Finally,
further studies should be planned on other potentially important
effects, that could not be considered in this study, such as those on
prenatal development, the cardiovascular system and the thyroid
gland. PMID: 12197280 [PubMed - indexed for MEDLINE]
JWN - please explain the following statements and enlighten me - I
thought you said amalgam was definitely safe?! Why are all these
scientists wasting society's valuable resources continuing to investigate
this "non-issue" ? (sarcasm intended)
"...HgU and HgB levels are significantly related to the presence of
dental amalgams and to fish consumption"
"However, possible effects of low doses of mercury on immune and
neuroendocrine functions should be further examined"
"Finally, further studies should be planned on other potentially important
effects, that could not be considered in this study, such as those on
prenatal development, the cardiovascular system and the thyroid gland"
- Next message: Alexander Vasserman DDS., BS.: "Re: Invisalign question"
- Previous message: Jan: "Re: Ping JWN"
- In reply to: JWN DDS: "Re: Ping JWN"
- Next in thread: Clinton C Zimmerman: "Re: Ping JWN"
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