Re: periostat?


Slightly more detailed reply:


Adv Dent Res. 1998 Nov;12(2):32-9. Related Articles, Links


Long-term sub-antimicrobial doxycycline (Periostat) as adjunctive
management in adult periodontitis: effects on subgingival bacterial
population dynamics.

Thomas JG, Metheny RJ, Karakiozis JM, Wetzel JM, Crout RJ.

Department of Pathology, West Virginia University, Morgantown
26506-9203, USA.

Previous trials had indicated that various schedules of
sub-antimicrobial doxycycline significantly reduced gingival crevicular
fluid (GCF) collagenase activity in adult patients with periodontitis
with no evidence of emergent tetracycline-resistant (Tcr) marker oral
flora. The purpose of this nine-month study was to expand these
observations, emphasizing newer microbial diagnostic methods.
Subgingival paper point samples were obtained at baseline (BL), 3, 6,
and 9 months. Four subject treatment groups in a double-blind design
were evaluated by mechanical scaling and root planing (SRP) and/or 20
mg doxycycline BID (Periostat). Thirty-eight patients entered the study
at baseline (BL). Dark-field microscopy on 260 samples showed that
morphotype distribution was independent of treatment schedule. Culture
analysis of the 3 most prevalent isolates recovered showed that
Streptococcus and Prevotella species accounted for approximately 85% of
the 724 cultures. There did not appear to be any overgrowth or
replacement by opportunistic oral flora. Of 658 susceptibility patterns
evaluated by Etest, the MIC50/90 and mode MIC showed stable patterns,
independent of treatment group. Our findings were different from those
of previously published reports, but may be partly explained by the
lack of universally standardized methods in oral microbiology and
interpretive criteria for susceptibility testing.

Publication Types:
Clinical Trial
Randomized Controlled Trial


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