Re: Question re bone graft

On 26 Sep 2005 13:16:14 -0700, "Sue" <chrlie699@xxxxxxxxx> wrote:

>JOel,
>
>Myocardial matrix metalloproteinases are released in heart failure and
>are responsible for the breakdown of the extracellular myocardial
>matrix. Based on past study, the current thought is that activation of
>myocardial MMPs contribute to adverse LV remodelling. This contributes
>to the progression of heart failure disease process.
>
>To my knowledge however, drugs that block the induction and activation
>of myocardial MMPs have not shown any initial benefits for HF
>patients.... I would have too look it up in the lit however.

Me too! I am a little behind with my reading ........ quite
fortunately, this is a relaxed, off-the-cuff talk site so no one will
hold anyone else's feet to the fire about our unresearched opinions.

In person, I am a little more cautious though!

Joel



>
>These may have not even been tested. Enbrel, a tumor necrosis
>factor-alpha antagonist actaully showed increased mortality in clinical
>trial of HF patients. Thus blocking this proinflammatory cytokine
>(apparent attempt to modulate the inflammatory response) did not
>benefit HF patients as was hoped.
>
>-Sue

.

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