Re: Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth

From: petergabreil (petergabreil_at_hotmail.com)
Date: 09/28/04 

Date: 27 Sep 2004 21:41:03 -0700

rbystrianyk@gmail.com (Roman Bystrianyk) wrote in message news:<4f28e591.0409161651.33721989@posting.google.com>...
> http://www.healthsentinel.com/news.php?id=246&title=Anti-cancer+Compound+In+Vegetables+Found+To+Block+Late-stage+Breast-cancer+Cell+Growth&event=news_print_list_item
>
> "Anti-cancer Compound In Vegetables Found To Block Late-stage
> Breast-cancer Cell Growth", Science Daily, September 1, 2004,
> Link: http://www.sciencedaily.com/releases/2004/09/040901091511.htm
>
> A well-known anti-cancer agent in certain vegetables has just had its
> reputation enhanced. The compound, in broccoli and other cruciferous
> vegetables, has been found to be effective in disrupting late stages
> of cell growth in breast cancer. Keith Singletary and doctoral student
> Steven Jackson of the University of Illinois at Urbana-Champaign
> report their finding involving sulforaphane (SUL), which they say
> could ultimately be used to enhance the prevention and treatment of
> breast cancer, in the September issue of the Journal of Nutrition.
>
> "This is the first report to show how the naturally occurring plant
> chemical sulforaphane can block late stages of the cancer process by
> disrupting components of the cell called microtubules," said
> Singletary, a professor in the department of food science and human
> nutrition. "We were surprised and pleased to find that SUL could block
> the growth of breast cells that were already cancerous."
>
> SUL is abundant in such vegetables as broccoli, brussels sprouts and
> kale. Chewing causes the cell walls of these vegetables to break, and
> SUL is released into the body.
>
> Singletary, a researcher in phytochemicals and cancer chemoprevention,
> and Jackson exposed cultures of malignant human breast cancer cells to
> SUL. Within hours, SUL blocked cell division and disrupted
> microtubules, which are long, slender cylinders made up of tubulin
> (protein), that are essential for the separation of duplicated
> chromosomes during cell division.
>
> "It is not yet clear whether the doses required to produce inhibition
> of tubulin polymerization are higher than those achievable via dietary
> intakes," wrote Jackson and Singletary. "However, the results show
> that tubulin disruption may be an important explanation for SUL's
> antiproliferative action."
>
> "These findings are significant since SUL's actions appear similar to
> a group of anticancer drugs currently in use, such as Taxol,"
> Singletary said.
>
> SUL is studied extensively for its effects against cancer. Previous
> reports have shown that SUL induces defensive mechanisms that are
> effective in protecting normal cells from the initiation of cancer.
> "More than 10 years ago, researchers at Johns Hopkins University
> reported that SUL is a potent inducer of enzyme systems that can
> defend against carcinogens," Singletary said. Such defense mechanisms
> are effective during the early stage of cancer.
>
> The Illinois research extends the 1992 discovery at Johns Hopkins and
> pinpoints how SUL works during later stages of cancer, such that SUL
> can suppress the orderly division process in human breast cancer
> cells.
>
> "The findings may be helpful in the development of new breast cancer
> prevention and treatment strategies," Singletary said. "For example,
> it may be possible that ingesting SUL in combination with certain
> natural compounds or drugs could enhance their anticancer
> effectiveness and reduce side effects."
>
> According to the American Cancer Society, breast cancer this year will
> account for 15 percent of all cancer deaths in women, and
> approximately 275,000 new breast cancer cases of various forms will be
> diagnosed.
>
> Improvements in treatments such as chemotherapy have led to an 88
> percent survival rate in Caucasian women and a 74 percent survival
> rate in African-American women, according to the most recent ACS
> survey in 2003.
>
> However, some current chemotherapy drugs have side effects that have
> the ACS and other organizations seeking new strategies that combine
> chemotherapy drugs with other treatments to potentially lessen the
> toxic effects.
>
> The new Illinois study confirms a previous study in mice. In the
> February 2004 issue of the journal Carcinogenesis, Singletary and
> Jackson reported that SUL treatments in mice with implanted cancer
> cells resulted in decreased tumor size.
>
> More research is needed to assess SUL's potential in countering breast
> cancer development, Singletary said. "What we do not know is how
> specific SUL and other similar phytochemicals are toward cancer cells
> compared to normal cells," he said. "We also do not know against which
> cancers SUL's microtubule-targeting actions are most effective."
>
> Future studies in Singletary's lab will address those issues.
>
> The University of Illinois Agricultural Experiment Station and the
> U.S. Department of Agriculture funded the research.

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