Re: Tarceva: New Drug Against Lung Cancer

From: J (quad_at_privacy.net)
Date: 11/21/04 

Date: Sun, 21 Nov 2004 18:56:01 -0500

http://cancer.duke.edu/btc/Resources/PatientEducation/Tarceva%20Rash.pdf
Rash Associated with TarcevaTM

Acne-like rashes are a common side effect of TarcevaTM. In most patients who have received
TarcevaTM in the
past, the rash was mild to moderate in severity. In some patients, this rash responded well to oral
antibiotics and
antibiotic creams used to treat regular acne.

Your dose of TarcevaTM may increase or decrease based upon the development of a rash. If the rash
is tolerable
to you, your dose of TarcevaTM will be increased every 2 weeks until you develop an intolerable
rash (itching or
irritating) or until the maximum allowable dose is reached. Once you develop an intolerable rash,
you will be
maintained on that dose of TarcevaTM and your symptoms will be managed with antibiotic and/or
steroid creams.
If your rash becomes intolerable while using the creams, your TarcevaTM dose will be decreased
until your rash is
tolerable.
Please see your local family doctor when you first notice what you think is a rash to get
confirmation.
If your doctor confirms you have a rash, call the study coordinator. Call the study coordinator
again when your
rash becomes intolerable. At the first appearance of a symptomatic rash, you will return to clinic
to get the
rash photographed. All patients will have an appointment scheduled to return to clinic at week 2.
The study
coordinator will call you the day before your scheduled appointment to assess the rash. If the
symptomatic rash
is present, you will return for your week 2 appointment. All patients will return 4 weeks after
starting TarcevaTM
to be examined and for labwork, and every 4 weeks thereafter. You will also receive a telephone
call from the
study coordinator every 2 weeks to assess for a rash and other possible adverse effects until the
maximum
tolerated dose of TarcevaTM is reached.

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