Re: Cancer, aspirin and statins...


"James Michael Howard" <jmhoward@xxxxxxxxxxxxxxxx> wrote in message
news:59ro81tg1u21qvn99tdhf9l52af252b1kv@xxxxxxxxxx
> On Thu, 19 May 2005 01:09:45 GMT, "Steph" <steph@xxxxxxxxxxxxxxxxx> wrote:
>
>>
>>"James Michael Howard" <jmhoward@xxxxxxxxxxxxxxxx> wrote in message
>>news:njrm81duequbjvguk6khrqve8joulpie6h@xxxxxxxxxx
>>> It is my hypothesis (1994) that testosterone increases breast cancer,
>>> and
>>> other
>>> caner, rates ("Testosterone may cause breast cancer," International
>>> Journal of
>>> Cancer 2005; 115: 497 and Annals of Internal Medicine 2005; 142: 471-2).
>>>
>>
>>If it were that simple, breast cancer would be common in men......
>>
>>> Statins reduce cellular production of testosterone up to 52% (Fertil
>>> Steril.
>>> 2004 Oct;82 Suppl 3:1193-7). Aspirin, which also reduces cancer with
>>> prolonged
>>> use also reduces testosterone. I suggest this supports my hypothesis
>>> that
>>> testosterone is involved in the initiation of breast cancer.
>>>
>>> James Michael Howard
>>> Fayetteville, Arkansas
>>
>
> You forgot Ockham's razor. First, start with the simpeist explanation.
> Next,
> you have to understand that women have two hormones at work, estradiol and
> testosterone affected their breasts. Men have one hormone at work. Also,
> you
> need to know that a number of reports have supported my hypothesis
> regarding the
> importance of testosterone in breast cancer in women. One says that
> testosterone may be more important than estradiol: "testosterone might be
> more
> strongly associated with [breast cancer] risk than estradiol" (Journal of
> the
> National Cancer Institute 2002; 94: 606-616). "The estimated relative
> [breast
> cancer] risks between upper and lower tertiles were 2.07 (95% confidence
> interval [CI] 0.97-4.41) for estrone in postmenopausal women, 2.01 (95% CI
> 0.96-4.21) for testosterone in premenopausal women, and 2.40 (95% CI
> 1.11-5.21)
> for testosterone in postmenopausal women, after adjusting for age at first
> live
> birth, waist-to-hip ratio, total calorie intake, a history of
> fibroadenoma, a
> family history of breast cancer and SHBG." (International Journal of
> Cancer
> 2003; 105: 92-7). ...and here is, I think, the latest: "CONCLUSIONS: Our
> results support the hypothesis that elevated blood concentrations of
> androgens
> are associated with an increased risk of breast cancer in premenopausal
> women."
> (J Natl Cancer Inst. 2005 May 18;97(10):755-65).
>
>
>

And I think you need to get a grip.
The complex interaction between oestrogen and testosterone undoubtedly has a
profound influence on both benign and malignant breast tissue.
But your statements that "testosterone increases breast cancer" or
"Testosterone may cause breast cancer," are simplistic nonsense - the test
being the simple one I stated


.

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