reason for increase in childhood cancers...
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Mon, 15 Aug 2005 19:32:56 GMT
Childhood Cancer, Possible Increase in Childhood Cancer, Engine Emissions, the
Secular Trend and Testosterone
(http://www.anthropogeny.com/Childhood%20Cancer.htm )
Copyright 2005, James Michael Howard, Fayetteville, Arkansas, U.S.A.
(Re: Journal of Epidemiology and Community Health 2005; 59: 101-105
Main results: Significant birth proximity relative risks were found within 1.0
km of hotspots for carbon monoxide, PM10 particles, VOCs, nitrogen oxides,
benzene, dioxins, 1,3-butadiene, and benz(a)pyrene. Calculated attributable
risks showed that most child cancers and leukaemias are probably initiated by
such exposures.
Conclusions: Reported associations of cancer birth places with sites of
industrial combustion, VOCs uses, and associated engine exhausts, are confirmed.
Newly identified specific hazards include the known carcinogens 1,3-butadiene,
dioxins, and benz(a)pyrene. The mother probably inhales these or related
materials and passes them to the fetus across the placenta. )
This report may be explained by increased maternal testosterone as a result of
exposure to these chemicals, especially nitrogen dioxide.
In 2004, I wrote "Negative Effects of Nitrogen Dioxide May be due to
Testosterone" (http://www.anthropogeny.com/NO2%20and%20testosterone.htm )
"Nitrogen dioxide is a ?pollutant? that is created by burning fuels. The main
sources are power plants and motor vehicles. It is known to cause problems for
people including increased susceptibility to respiratory infections, snoring,
lung problems, etc. I suggest nitrogen dioxide may cause its problems because
nitrogen dioxide may increase testosterone in humans as it does in rats (below).
Increased testosterone may be involved in a number of diseases and mortality.
This areas has not been studied very much; in rats, nitrogen dioxide increases
testosterone (Environ Health Perspect 2001; 109: 111-9 and ibid 1999; 107:
539-44)."
Baik, et al., recently reported "These findings indicate that levels of growth
factors and hormones [testosterone] are strongly associated with stem cell
potential in human umbilical cord blood and point to a potential mechanism that
may mediate the relationship between in utero exposure to hormones and cancer
risk in the offspring." (Cancer Res. 2005 Jan 1;65(1):358-63).
I suggest the basis of this report may be directly connected to induction of
increased maternal testosterone levels which may induce future malignant
transformations.
In 1994 I first suggested that testosterone may be involved in causing cancer
(International Journal of Cancer 2005; 115: 497 and Annals of Internal Medicine
2005; 142: 471-472). Since there may be some indication that increased maternal
testosterone may be involved in childhood cancers (the foregoing part of this
treatise), I concluded that childhood cancer should be increasing because of the
?secular trend.? It is my hypothesis that the "secular trend," the increase in
size and earlier puberty in our children is actually caused by an increase in
percentage of individuals of higher testosterone within our population over
time. This is driven by women of higher testosterone. I did find information
from the ?National Cancer Institute? that childhood cancer may be increasing
(2005). Therefore, I suggest this possible increase in childhood, and adult,
cancers may be due, alone, to the secular trend and this may be exacerbated by
exposure to chemicals, especially engine exhausts.
.
- Follow-Ups:
- Re: reason for increase in childhood cancers...
- From: Steph
- Re: reason for increase in childhood cancers...
- Prev by Date: Re: Treatment at John Hopkins
- Next by Date: Re: toleration of chemotherapy
- Previous by thread: Treatment at John Hopkins
- Next by thread: Re: reason for increase in childhood cancers...
- Index(es):
Relevant Pages
|
