Omega-3 fatty acids and cancer

Below some recent studies and reviews about omega-3 fatty acids and cancer
together with some earlier reviews and major studies:

Menendez JA, Lupu R, Colomer R.
Exogenous supplementation with omega-3 polyunsaturated fatty acid
docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane
cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in
human breast cancer cells.
Eur J Cancer Prev. 2005 Jun;14(3):263-70.
PMID: 15901996 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15901996>

S.-H. Xia, J. Wang, and J. X. Kang
Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human
lung cancer cells by downregulation of cell adhesion/invasion-related genes
Carcinogenesis, April 1, 2005; 26(4): 779 - 784.
<http://carcin.oxfordjournals.org/cgi/content/abstract/26/4/779>

Maclean CH, Newberry SJ, Mojica WA, Issa A, Khanna P, Lim YW, Morton SC,
Suttorp M, Tu W, Hilton LG, Garland RH, Traina SB, Shekelle PG.
Effects of omega-3 fatty acids on cancer.
Evid Rep Technol Assess (Summ). 2005 Feb;(113):1-4. Review.
PMID: 15777113 [PubMed - indexed for MEDLINE]
<http://www.ahrq.gov/downloads/pub/evidence/pdf/o3cancer/o3cancer.pdf>

Hardman WE.
(n-3) fatty acids and cancer therapy.
J Nutr. 2004 Dec;134(12 Suppl):3427S-3430S. Review.
PMID: 15570049 [PubMed - indexed for MEDLINE]
<http://www.nutrition.org/cgi/content/full/134/12/3427S>

Terry PD, Terry JB, Rohan TE.
Long-chain (n-3) fatty acid intake and risk of cancers of the breast and the
prostate: recent epidemiological studies, biological mechanisms, and
directions for future research.
J Nutr. 2004 Dec;134(12 Suppl):3412S-3420S. Review.
PMID: 15570047 [PubMed - indexed for MEDLINE]
<http://www.nutrition.org/cgi/content/full/134/12/3412S>

Calviello G, Di Nicuolo F, Gragnoli S, Piccioni E, Serini S, Maggiano N,
Tringali G, Navarra P, Ranelletti FO, Palozza P
n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the
COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
Carcinogenesis. 2004 Dec;25(12):2303-10. Epub 2004 Sep 9.
PMID: 15358633 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15358633>

Siddiqui RA, Shaikh SR, Sech LA, Yount HR, Stillwell W, Zaloga GP.
Omega 3-fatty acids: health benefits and cellular mechanisms of action.
Mini Rev Med Chem. 2004 Oct;4(8):859-71. Review.
PMID: 15544547 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15544547>

Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC,
Giovannucci EL.
Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer.
Am J Clin Nutr. 2004 Jul;80(1):204-16.
PMID: 15213050 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/80/1/204>

Jho DH, Cole SM, Lee EM, Espat NJ.
Role of omega-3 fatty acid supplementation in inflammation and malignancy.
Integr Cancer Ther. 2004 Jun;3(2):98-111. Review.
PMID: 15165497 [PubMed - indexed for MEDLINE]
<http://ict.sagepub.com/cgi/content/abstract/3/2/98>

Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A.
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of
potential mechanisms.
Am J Clin Nutr. 2004 Jun;79(6):935-45. Review.
PMID: 15159222 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/79/6/935>

Roynette CE, Calder PC, Dupertuis YM, Pichard C.
n-3 polyunsaturated fatty acids and colon cancer prevention.
Clin Nutr. 2004 Apr;23(2):139-51. Review.
PMID: 15030953 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15030953>

Shahidi F, Miraliakbari H.
Omega-3 (n-3) fatty acids in health and disease: Part 1--cardiovascular
disease and cancer.
J Med Food. 2004 Winter;7(4):387-401. Review.
PMID: 15671680 [PubMed - indexed for MEDLINE]
<http://www.liebertonline.com/doi/abs/10.1089%2Fjmf.2004.7.387?cookieSet=1>

Hardman WE.
Omega-3 fatty acids to augment cancer therapy.
J Nutr. 2002 Nov;132(11 Suppl):3508S-3512S. Review.
PMID: 12421878 [PubMed - indexed for MEDLINE]
<http://www.nutrition.org/cgi/content/full/132/11/3508S>

Terry P, Lichtenstein P, Feychting M, Ahlbom A, Wolk A.
Fatty fish consumption and risk of prostate cancer.
Lancet. 2001 Jun 2;357(9270):1764-6.
PMID: 11403817 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11403817>

Rose DP, Connolly JM.
Omega-3 fatty acids as cancer chemopreventive agents.
Pharmacol Ther. 1999 Sep;83(3):217-44. Review.
PMID: 10576293 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10576293>

Bougnoux P.
n-3 polyunsaturated fatty acids and cancer.
Curr Opin Clin Nutr Metab Care. 1999 Mar;2(2):121-6. Review.
PMID: 10453342 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10453342>

--
Matti Narkia
.

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