Re: Nanobacteria Link to Cancer: Nexus Magazine Article

Steph....Here's a scientific study published in the research Journal of
Histopathology linking Nanobacteria Infection with Ovarian Cancer.

Histopathology
Volume 45 Issue 6 Page 633 - December 2004
doi:10.1111/j.1365-2559.2004.02030.x


Presence of nanobacteria in psammoma bodies of ovarian cancer: evidence
for pathogenetic role in intratumoral biomineralization
G Hudelist1,2, C F Singer1, E Kubista1, M Manavi1, R Mueller3, K
Pischinger3 & K Czerwenka3
Hudelist G, Singer C F, Kubista E, Manavi M, Mueller R, Pischinger K &
Czerwenka K
(2004) Histopathology45, 633-637
Presence of nanobacteria in psammoma bodies of ovarian cancer: evidence
for pathogenetic role in intratumoral biomineralization
Aims: The presence of laminated, calcified extracellular debris known
as psammoma bodies is a well-known histomorphological feature of
ovarian adenocarcinomas and other human malignancies. Biomineralization
has recently been found to be associated with a group of extremely
small Gram-negative bacteria capable of precipitating calcium salts.
The aim of the present study was to evaluate a possible pathogenic link
between the development of psammoma bodies and nanobacteria infection.

Material and results: Immunohistochemical staining and reverse
transcriptase-polymerase chain reaction (RT-PCR) were used to analyse
nanobacterial protein and gene expression in eight psammona
body-containing adenocarcinomas and in 10 malignant ovarian tumours
without signs of biomineralization. Nanobacterial proteins were
detected in eight out of eight (100%) psammoma-positive tumour samples.
Conversely, none of the 10 psammoma-negative tissues (0%) was positive
for nanobacterial antigens. Furthermore, nanobacterial mRNA was
detectable in all of the four tissues (100%) that contained psammoma
bodies, but was absent in all 10 ovarian cystadenocarcinomas (0%) that
were psammoma negative.

Conclusions: We found a 100% concordance between the expression of
nanobacteria and the presence of psammoma bodies in malignant ovarian
tumours. Several lines of evidence suggest the involvement of these
organisms in the process of biomineralization. We therefore conclude
that nanobacterial infection of malignant ovarian tissue contributes to
mechanisms leading to the formation of calcified deposits known as
psammoma bodies.

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