Re: New Drug Might Help Prevent Breast Cancer
- From: J <studydras@xxxxxxxx>
- Date: Sat, 12 Nov 2005 05:47:03 -0500
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15255284&dopt=CitationGynecol
Endocrinol. 2004 Mar;18(3):152-8. Related Articles, Links
Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in
healthy postmenopausal women.
Komi J, Heikkinen J, Rutanen EM, Halonen K, Lammintausta R, Ylikorkala O.
Hormos Medical Corporation, Turku, Finland.
Ospemifene is a novel selective estrogen receptor modulator (SERM). Here we
studied the effects of ospemifene on bone turnover in postmenopausal women. This was a
randomized, double-blind study in which 159 healthy postmenopausal women received 30
(n = 40), 60 (n = 40) or 90 mg (n = 40) of ospemifene or placebo (n = 39) for 3
months. Bone resorption was assessed by measuring the urinary outputs of N- and
C-terminal crosslinking telopeptides of type I collagen (NTX and CTX, respectively).
Bone formation was assessed by measuring the levels of procollagen type I N propeptide
(PINP), procollagen type I C propeptide (PICP), and bone-specific alkaline phosphatase
(bone ALP) in serum. All markers were studied at baseline, 3 months, and 2-4 weeks
after cessation of the medication. Ospemifene decreased bone resorption
dose-dependently, as seen from falls in NTX by 6.1, 9.4 and 12.9% in the 30, 60 and 90
mg ospemifene groups, respectively (p < 0.05 for all dose levels when compared to
placebo). CTX values decreased in the 90 mg ospemifene group by 4.8% (p < 0.05). A
dose-dependent decrease was also observed in the bone formation markers: PINP values
decreased by 9.8 (p < 0.05) and 15.3% (p < 0.01), and PICP values by 12.0 and 11.9% in
the 60 and 90 mg ospemifene groups, respectively. Bone ALP decreased in 60 and 90 mg
ospemifene groups by 1.9 and 2.6%, respectively (p < 0.05 for both dose levels when
compared to placebo). These results show that ospemifene is effective in reducing bone
turnover in postmenopausal women.
.
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