"Survivin"

http://www.clinicaltrials.gov/ct/show/NCT00108875?order=1

Survivin Peptide Vaccination for Patients With Advanced Melanoma,
Pancreatic, Colon and Cervical Cancer

This study is currently recruiting patients.
Verified by Julius-Maximilians University June 2005
Sponsored by: Julius-Maximilians University
Information provided by: Julius-Maximilians University
ClinicalTrials.gov Identifier: NCT00108875

Purpose
This study evaluates the safety, the immunological response and the
clinical outcome of a vaccination with survivin peptides for patients with
advanced melanoma, pancreatic, colon and cervical carcinoma.
Condition Intervention Phase Phase I Phase II
Malignant Melanoma
Pancreatic Cancer
Colon Cancer
Cervical Cancer
Vaccine: Survivin peptide vaccine


<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=332>

Official Symbol: BIRC5 and Name: baculoviral IAP repeat-containing 5
(survivin) provided by HUGO Gene Nomenclature Committee
See related: HPRD:04520, MIM:603352
Gene type: protein coding
Gene name: BIRC5
Gene description: baculoviral IAP repeat-containing 5 (survivin)
RefSeq status: Reviewed
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
Homo
Gene aliases: API4; EPR-1
Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene
family, which encode negative regulatory proteins that prevent apoptotic
cell death. IAP family members usually contain multiple baculovirus IAP
repeat (BIR) domains, but this gene encodes proteins with only a single
BIR domain. The encoded proteins also lack a C-terminus RING finger
domain. Gene expression is high during fetal development and in most
tumors yet low in adult tissues. Antisense transcripts are involved in the
regulation of this gene's expression. At least four transcript variants
encoding distinct isoforms have been found for this gene, but the
full-length natures of only three of them have been determined.

http://www.sciencedaily.com/releases/2000/07/000705060237.htm
Date: 2000-07-05

<http://www.findarticles.com/p/articles/mi_qa3725/is_200307/ai_n9295583>


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