Re: liver question

Another study for your consideration ...

Ju-Hua Chen, George L Tipoe, Emily C Liong, Henry SH So, Ka-Man Leung,
Wai-Ming Tom, Peter CW Fung, and Amin A Nanji, "Green tea polyphenols
prevent toxin-induced hepatoxicity in mice by down-regulating inducible
nitric oxide-derived prooxidants", Advances in Therapy, September 1,
2004, Vol. 80, Num. 0, pp. 742-751
"There has been a great deal of interest recently in the role of
complementary and alternative medicines for the treatment of various
acute and chronic diseases. Of the various herbal and botanical agents
available, interest has focused on the anti-inflammatory and
antioxidant properties of polyphenols found in green tea. The green tea
polyphenols include epigallocatechin gallate (EGCG), epigallocatechin,
epicatechin gallate, and epicatechin. Of these polyphenolic components
of green tea, EGCG is the major constituent and is also the component
with the highest antioxidant properties."

"Because oxidative stress plays a major role in several liver
diseases, it was of interest to evaluate the role of green tea
polyphenols protecting against liver injury."

"Many studies carried out over the past few years have shown that the
polyphenolic fractions isolated from green tea inhibit oxidant stress
and possess antiinflammatory activity. In this study we showed that
treatment with EGCG markedly inhibits acute hepatocellular injury in a
well-characterized murine model of liver toxicity. The initial step in
liver injury caused by carbon tetrachloride is the formation of
trichloromethyl free radical; subsequent activation of Kupffer cells
with the release of proinflammatory mediators is believed to be a
crucial event in hepatic toxicity. Our results provide evidence that
the protective effect of EGCG against tetrachloride-induced toxicity
is, at least in part, mediated through the inhibition of NO expression
and down-regulation of the production of proinflammatory mediators
resulting from induction of iNOS."

"Thus, the main finding of the current study was that carbon
tetrachloride elicited acute liver injury as indicated by a significant
increase in hepatocellular damage, increased alanine aminotransferase
activity in serum, increased expression of iNOS, and extensive
nitrotyrosine formation. By comparison, the degree of liver injury and
expression of iNOS and nitrotyrosine decreased significantly in the
EGCG-treated mice. Although our study focused on the role of EGCG in
preventing hepatic toxicity, it is important to point out that the
overall protective effect of green tea may require the combined actions
of several components of green tea. Relevant to the findings of the
current study is the observation by Tedeshi et al, which showed that a
consumption of 10 cups of green tea exerts inhibitory actions on
cytokine-induced tyrosine phosphorylation that blocks the expression of
iNOS and reduces NO production. Because green tea can be consumed over
long periods of time without any obviously known side effects, its
possible role as an adjunct therapeutic agent in human inflammatory
liver disease deserves consideration."

.

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