Mutations in the breast tumors were substantially different from those in the colorectal tumors.

but then they don't tell us which type of breast cancer, they were
comparing to.
J

<http://www.latimes.com/news/printedition/asection/la-sci-cancer9sep09,1,1762957.story?coll=la-news-a_section>

Many Mutations Found in Colon, Breast Cancer
Genetic mapping may lead to better treatment and ways to prevent tumors,
scientists say.
From the Associated Press
September 9, 2006

Scientists mapping the genetics of two of the nation's leading cancers
have found almost 200 mutated genes in breast and colorectal tumors, many
of them never before suspected of helping cancer form and spread.

Doctors have long known it takes a cascade of genetic flaws to trigger any
of the myriad types of cancer. Which genes are working improperly also
determines if a malignancy is especially aggressive, and even whether a
particular treatment is likely to work.

Finding those genes-run-amok could lead to better cancer treatments and
even ways to prevent tumors. But scientists have found only a fraction of
them.

Now, armed with better technology, a quest is beginning to comprehensively
map the genetic makeup of different cancers.

On Thursday, scientists at Johns Hopkins University had their first big
success reported in the online version of the journal Science: They
examined more than 13,000 genes in 11 different breast tumors and 11
colorectal cancers removed from patients during surgery. They found 189
mutated ones that seem to play a role in those two types of cancer.

The number of potential culprits was surprising; researchers had expected
to find a few, not dozens.

Importantly, the work emphasizes that cancers differ greatly from organ to
organ: Mutations in the breast tumors were substantially different from
those in the colorectal tumors.

Now the harder work begins: figuring out exactly what those altered genes
do, and whether there are ways to target them.


.

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