Re: madiba and/or Steph
- From: down@xxxxxxxxxxxx (madiba)
- Date: Sat, 16 Sep 2006 12:07:06 +0200
J <macyinno@xxxxxxxxxx> wrote:
madiba wrote:
J <macyinno@xxxxxxxxxx> wrote:
J wrote:
madiba wrote: From the breast cancer newsgroup:
Its also being tested experimentally as a preventative drug against
cancer, so far it looks promising. As to side effects, its been used by
2 million people as an anti-malarial, so far no significant sideeffects..
All in all a very interesting drug.
Oh sorry, I missed the above.
But only (perhaps) useful in (prevention of) viral-related cancers?
Why? Its effective and thats what counts, at least in lab animals. Whats
this virus-fixation? Do you think malaria is caused by a virus? :-/
It's caused by a parasite, but they're talking anti-viral here
(and anti-bacterial, anti-fungal)
http://clinicaltrials.gov/ct/show/NCT00284687?order=7
If you care to explain how you think it might help sarcomas, I'm listening.
Thanks
It worked in dog sarcomas. The killing mechanism elucidated so far
refers to Plasmodium and breast carcinoma, but one can assume the same
mechanism works for sarcoma:
Both cancer cells and Plasmodium store lots of intracellular iron, but
for different reasons. The one collects iron (heme) as 'trash' (60000
molecules/minute/parasite) while gobbling haemoglobin, the cancer cell
stores the iron to use in rapid cell division (for the ribose->
deoxyribose reaction). When Artemisinin enters the cell its unstable
endoperoxide bridge reacts with the iron to trigger free radicals which
in turn kill the tumor cell / malaria parasite.
--
madiba
.
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