Re: Need advice on clinical trials

mainframetech <choughton@xxxxxxxxxxxxx> wrote:

J,
Thank you for the information. Peter may also appreciate it, since
he had asked me for that type of info. He might want the link to it.

Peter,
Please stop taking personal issue with what I say. I promise I'm
not out to insult you, only defend my point of view from your
viewpoint.

Artemisinin is not simply an alternative herb. Not if the Gates
Foundation is applying it to many patients for malaria.
Malaria is not cancer, so quit trying to squeeze more out of this fact
than its worth. Or did you see anyone here saying it DIDN'T work as an
antimalarial?.

Interestingly enough, if you have a medical background you'll appreciate
that the scientists and doctors that have commented on the Artemisinin
studies say that it kills cancer in the same way it kills the malaria
parasite. It apparently is drawn to the iron-rich cancer (or malaria host)
cells and kills the cells (apoptosis?) when in the presence of an
overabundant amount of iron. It seems to leave the normal cells alone.
You can see where this method would be more able to kill cancer in the
fine interstices of the body that surgery or maybe directed radiation
might miss. Happily, because of the Gates Foundation, we know the
compound is safe for humans, and painless.
another word from our magnanamous sponsor..
The fact that millions of asians took artemisinin without side-effects
long before Bill Gates made his first million doesn't seem to bother
you..

Again, I suggest to all seekers here to research 'Artemisinin' and
the 2 doctors that have been studying it; Drs. Henry Lai and Narendra
Singh at the University of Washington. This compound can be taken at
the same time as many other treatments and not get in the way. I think
there is only a problem with radiation therapy where you have to wait a
while. Have a look at the compound and make your decisions.
in vitro stuff, as Peter mentioned.

Chris
J wrote:
PM wrote:

PM wrote:
IIRC their work was entirely in the test tube, and under very
artificial conditions at that (heavy iron loading of the cells that is
probably impractical in vivo). I am also unaware of any evidence that
Artemisin has yet shown any clinical effectiveness, i.e. effects on
cancer in humans, although I understand it is under study in some
places. Do you have any better evidence to present?

<snipped some>

This is a bit unfair. I actually checked Medline to see if there were
any recent
publications of clinical results from Artemisinin before I posted my
comments. . I even asked you politely if you had any clinical
evidence. I am trying to keep up to date on this kind of thing all
the time.

There's one case report, 6 years ago here
<http://www.onk.ns.ac.yu/archive/Vol10/PDFVol10/V10n4p279.pdf> A
seventy-two year old vegetarian male with a long history of tobacco
chewing and smoking was admitted to Vivekanand Hospital (Meerut, India)
on December 15, 2000.
One case = anecdote..

stage II cancer of the larynx (T2 N1 M0). A diagnosis of differentiated
squamous cell carcinoma was established after histopathological
examination of a biopsy from the growth. The patient complained of
plained of progressive hoarseness, and loss of appetite and weight for
the last eight months. Physical examination revealed enlarged cervical
lymph nodes on the right side of the neck

Laryngoscopic examination showed a growth on the right side of the
larynx. The growth was covering the right vocal cord, right pyriform
fossa, ventral aspect of epiglottis, and adjacent area of the lateral
pharyngeal wall. The surface of the growth was irregular, nodular,
ulcerated and bled on touch. Its size was approximately 3 cm x 2.5 cm x
3 cm=22.5 cm
sounds more advanced than a T2 BTW..

[He'd had intermittent pain and swallowing difficulties for the previous 6
months. - me summarizing]

artesunate treatment was started on 01/22/2001. On day one of treatment,
a capsule containing ferrous sulfate (150 mg) and folic acid (0.5 mg)
was given orally at 2:00 PM after a meal. Injections of artesunate (60
mg I.M. per day; were given from day one (01/22/2001) to day 15
(02/05/2001) at 10:00 PM of each day.
There's the commercial opportunity: sell it in a combination pack!

The patient had a fever (100-101°F) from day four to day seven of the
treatment. Within two weeks of the treatment, his voice became clear.
The patient was able to take solid foods quite comfortably. He regained
a good appetite. Clinical examination revealed cervical lymph nodes were
reduced in size. Without treatment, laryngeal cancer patients die within
an average of 12 months (1). The patient lived for nearly one year and
eight months (until his death on 1/11/02 due to pneumonia) after the
appearance of symptoms, although treatment was discontinued after nine
months.
Hmm.. artemisinin (not sure of artesunate) is cheaper than most
antibiotics that could have cured the pneumonia.
Was a PM done?

In an unrelated note, the patients had extensive patches of leukoderma
around his mouth, on fingers of both hands, which responded well to
artesunate treatment over the nine months of observation.

Since this case, several patients with different types of cancers have begun
treatment with artemisinin and its analogs with promising results.

Narendra P. SINGH
Krishna B. VERMA
Archive of Oncology 2002;10(4):279-80.
The authors are grateful to Miss Himani Singh for her help in preparation of
the manuscript."

No idea what happened to the other patients mentioned.
I think it says the author (Singh) can be contacted.
J

It is also insulting to assume that I ever dismiss alternative claims
without looking closely at the evidence. My web site shows the lengths
to which I have been prepared to go in that regard. I am certainly
uncompromising in expecting the highest standard of case reports or
other evidence in support of such important claims as to be able to
cure cancer. I think that puts me firmly on the side of the cancer
patient.

I have also not objected to cancer patients working from lower levels
of evidence if they wish. The rest of us, however, should be working
to make sure that those selling or promoting such treatments are giving
cancer patients accurate information. They rarely ever do, and that
is what I am about.

Peter Moran

www.cancerwatcher.com


--
madiba
.

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