Re: cytoreductive surgery




"J W" <jonboy42@xxxxxxxxx> wrote in message
news:494-458CAACB-1693@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
I've been off chemo since Sept. 06 due to toxicity issues which caused
me to fail 1st line chemo basically. I'm stage IV colon cancer with
peritoneal signet ring cell mets. I had debulking surgery done
(omentectomy & peritoneum removed as much as possible) prior to standard
1st line Folfox w/ avastin chemo in Dec. 05.

My CEA has been gradually rising while off chemo from 8 to 12 to 18 and
now this month it jumped to 47. A freind in my colon cancer group gave
me some names of doctors that specialize in peritoneal cancers. One of
them in Baltimore has responded. He worked and studied under Dr.
Sugarbaker who invented IP chemo as I am told. He wants me to get a PET
scan to rule out lymph nodes being the CEA culprit since 13 of 13 nodes
came back positive at point of surgery and if that checks out he wants
me up there by 2nd week of Jan provided my ins. will cover it. for
cytoreductive surgery followed by heated (IP) chemo applied directly to
peritonial cavity.

Does this sort of treatment have any merit? Do you think it would
improve the odds (length of survival) any for a stage IV patient? Thus
far (knock wood) no mets have been found in any organs, all CAT scans
have come back clear. As I understand it from what I've found standard
(IV) systemic chemo is not very useful for peritonial signet ring cell
mets due to poor circulation in much of that area making it difficult to
deliver the chemo to the tumors. I know everyone says that stage IV of
this type is incurable, I understand that. I'm looking for anything
reasonable that won't make me worse or endanger my life that may buy
time, which hopefully something new will come along to help.





IP chemo, especially heated, is quite toxic, and the chemo only penetrates a
few cells of thickness. It is of absolutely no proven value in colon cancer


.



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