intraperitoneal hyperthermic chemotherapy

http://www.annalssurgicaloncology.org/cgi/content/full/10/2/155?ck=nck
Annals of Surgical Oncology 10:155-162 (2003

Long-Term Survivorship and Quality of Life After Cytoreductive Surgery
Plus Intraperitoneal Hyperthermic Chemotherapy for Peritoneal
Carcinomatosis
Richard P. McQuellon, PhD, Brian W. Loggie, MD, Anna B. Lehman, MA,
Gregory B. Russell, MS, Ronald A. Fleming, PharmD, Perry Shen, MD and
Edward A. Levine, MD

From the Departments of Internal Medicine (RPM, ABL, RAF), Section of
Hematology and Oncology, Public Health Sciences (GBR), and General Surgery
(PS, EAL), The Surgical Oncology Service, Wake Forest University School of
Medicine, Winston-Salem, North Carolina; and the Surgical Oncology Section
(BWL), Creighton University, Omaha, Nebraska.

Demographics and patient characteristics are listed in Table 1.

A total of 109 patients were treated at the Comprehensive Cancer Center of
Wake Forest University between January 1, 1992, and December 31, 1997.

Twenty-nine patients had survived >=3 years and were available for
analysis at the last recorded date of medical follow-up conducted before
the initiation of this study.

Of this group, 12 patients did not participate for the following reasons:
did not respond to repeated telephone calls (n = 5); were deceased (n =
3); were unable to complete because they were hospitalized (n = 2);
declined (n = 1); and had recurrent disease (n = 1).

A total of 17 patients were available for questionnaire response and
analysis. The mean time since initial treatment with IPHC was 5.3 ± 1.6
years (range, 3.1?8.0 years). In addition to omentectomy, peritoneal
surface debulking, and resection for all patients, 3 of 17 also underwent
splenectomy, and 10 of 17 had resection of bowel (either small [4 of 10]
or large [8 of 10]; 2 had both small- and large-bowel resections). The
resection status for each tumor type was recorded as follows: R0 =
appendix (n = 4), large intestine (n = 3), or ovary (n = 1); R1 = appendix
(n = 1) and large intestine (n = 1); R2a = appendix (n = 2) and large
intestine (n = 1); R2b = appendix (n = 3); and R2c = primary PC (n = 1).

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