The prognostic value of anaemia in locally advanced head and neck cancer

Dietl B, Marienhagen J, Schafer C, Kolbl O.
The prognostic value of anaemia at different treatment times in
patients with locally advanced head and neck cancer treated with
surgery and postoperative radiotherapy.
Clin Oncol (R Coll Radiol). 2007 May;19(4):228-33. Epub 2007 Mar 12.
PMID: 17433968 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17433968&query_hl=14&itool=pubmed_DocSum>

"AIMS: We report a retrospective mono-institutional analysis of
anaemia (<12g/dl) at different treatment times (preoperative,
postoperative, before radiotherapy and nadir levels during
radiotherapy) in head and neck cancer patients treated with
surgery and postoperative radiotherapy. The study objective was
to determine whether, and at which time points, anaemia had a
significant effect on the end points overall survival and local
recurrence-free survival (LRFS). MATERIALS AND METHODS: The end
points for the statistical analysis in 130 patients were LRFS
and overall survival. A univariate analysis (Log-rank test) was
carried out on the following variables with potential end
point-related impact: gender, T, N, G, American Joint Committee
on Cancer (AJCC) stage, tumour site, resection status, overall
treatment time (OTT), radiotherapy treatment time (RTT) and
preoperative, postoperative, pre-radiotherapy and nadir levels
of haemoglobin during radiotherapy. Individual variables with a
significant effect (P=0.05) were then subjected to multivariate
Cox regression analysis. RESULTS: The median overall survival
was 59 months. The univariate analysis showed that AJCC stage
(P=0.0268), resection status (P=0.0407), preoperative
haemoglobin level (P=0.0087), postoperative haemoglobin level
(P=0.0035), RTT (P=0.0042) and OTT (P=0.0343) significantly
influenced overall survival. OTT (P=0.0130) and postoperative
haemoglobin (P=0.0243) had a significant effect on LRFS. The
multivariate Cox regression analysis showed postoperative
haemoglobin <12g/dl and OTT>100 days to be independent negative
prognostic factors for both end points. CONCLUSIONS:
Postoperative acute anaemia <12g/dl and an OTT>100 days were
independent negative prognostic factors for LRFS and overall
survival in patients with head and neck cancer treated with
surgery and postoperative radiotherapy."


--
Matti Narkia
.

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