Screening for Second Malignancies in Survivors of Childhood Cancer: U.S. Perspective

http://2006.confex.com/uicc/uicc/techprogram/P10413.HTM

Sunday, 9 July 2006 - 1:55 PM
17-3
Screening for Second Malignancies in Survivors of Childhood Cancer: U.S.
Perspective
Gregory H. Reaman, MD, Children's Oncology Group, 4600 East West Hwy,
Suite 600, Bethesda, MD 20814

Several studies following large cohorts of childhood cancer survivors have
reported a 3-6 fold increase in the risk of developing a second cancer
when compared to cancer incidence in age matched controls.

Unfortunately this marked predisposition appears to increase as the
populations of these cohorts age.

Since current overall childhood cancer cure rates exceed 75% and currently
1 in 600 individuals under the age of 40 years is a survivor of childhood
cancer, improved understanding of the risk of second cancer, its
mechanism(s), and developing strategies for screening and prevention are
warranted.

Death from a subsequent, treatment-related cancer is the second leading
cause of mortality in childhood cancer survivors.

Younger age at treatment of the primary cancer is associated with the
highest risk of most second cancers excluding treatment-related
myelodysplastic syndromes. Age, genetic syndromes, cumulative exposure to
specific chemotherapy agents, and ionizing radiation exposure are all
associated with specific risks of certain cancers and must be considered
in developing universal screening strategies for this expanding population
of children, adolescents and young adults at risk.



Web Page: www.curesearch.org

See more of Screening for Second Tumors in Long-Term Survivors
See more of Cancer Research, Detection and Treatment

See more of The UICC World Cancer Congress 2006

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