Tumor-oriented anti-cancer agent with estrogen as a carrier

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd - [too long]
http://tinyurl.com/2wrn4h
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):1065-71.Links
[Tumor-oriented anti-cancer agent with estrogen as a carrier]
[Article in Japanese]

Ohsawa N, Yamazaki Z.

3rd Dept. of Internal Medicine, University of Tokyo Faculty of
Medicine, Hongo, Japan.

Tumor oriented anticancer agents with estrogen as a carrier have been
extensively studied since 1950's. Only Estracyt and bestrabucil have been
evaluated to be useful in clinical trials. Although the use of estrogen as
a carrier for anticancer agents aimed at the development of the anticancer
drug for the receptor mediated chemotherapy, these two drugs did not show
any affinity to estrogen receptor. The history tells us that the
development of anticancer agents for the estrogen receptor mediated
chemotherapy is extremely difficult. Estracyt is reported to exert its
anticancer effect on prostate cancer through the specific binding to the
estramustine binding protein (EMBP) which is present only in the prostate
gland and cancer. Bestrabucil shows the selective uptake by the various
malignant cells and is indicated that bestrabucil exerts its anti-cancer
effects on various malignant tumors including breast cancer and
hematopoietic malignancy, through the affinity to malignant cells. The
mechanism is unknown and to be elucidated.

PMID: 3291767 [PubMed - indexed for MEDLINE]

Related Links

* [Bestrabacil: a possible target-oriented anticancer agent] [Gan To
Kagaku Ryoho. 1984]
* [A new anti-cancer agent, bestrabucil (KM 2210): I. Concentration in
the serum and tissue in urogenital tumors] [Gan To Kagaku Ryoho. 1987]
* 2-Methoxyestradiol, a promising anticancer agent. [Pharmacotherapy.
2003]
* [Pharmacology and metabolism of a new therapeutic drug for prostatic
cancer "Estracyt"] [Gan To Kagaku Ryoho. 1984]
* Mechanism of retention of estramustine in the rat prostate and
results of a clinical trial of Estracyt in Japan. [Prostate. 1981]

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