Re: Cromolyn and pancreatic cancer question.
- From: J <xnswex@nalid;"no>
- Date: Sun, 30 Mar 2008 04:32:58 -0500
Phil wrote:
My mom was recently diagnosed with pancreatic cancer. The chemo of
choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
know this is only moderately effective.
There was a study on mice at M.D. Anderson medical center in which
they realized Cromolyn, in combination with the Gemcitibane, had a
MUCH more powerful impact on the tumors than the Gemcitibane alone.
Since no human studies have been approved yet- I think they are
trying
to improve the method of delivering it to the tumor- it is
frustrating
to know that there is this OTC medication that could help her, and
almost certainly cant hurt (compared to the near-certain prognosis of
pancreatic cancer).
My question is, if we wanted to simply add OTC chromalyn (sold for
allergies and asthma) to her regimen, what is the best method to get
a substantial amount into her body. The inhaler, or should we try to
convince a doctor to prescribe the tablet (cromolyn sodium) that gets
mixed in water? I read that absorbtion through the intestines is only
1% which is why, perhaps, they are trying to work on delivery. Would
inhalation be more effective? They also have eyedrops which I assume
are not effectively absorbed?
Thanks. Below is some of the info from abstract.
____________________________________-
Background: We previously found that S100P, a member of the S100
protein family, is expressed in more than 90% of pancreatic tumors
and
is associated with tumor growth and invasion. In the current study,
we
investigated the ability of the antiallergy drug, cromolyn, to block
S100P function. Methods: Interactions between cromolyn and S100P were
investigated using a drug affinity column and by examining cromolyn's
effects on coimmunoprecipitation of S100P and receptor for advanced
glycation end-products (RAGE). The effects of cromolyn on cell
growth,
invasion, and nuclear factor-B (NFB) activity of pancreatic cancer
cells with (BxPC-3 and MPanc-96) and without (Panc-1) endogenous
S100P
were investigated by cell proliferation assay, by cell invasion
assay,
and by luciferase reporter gene assay, respectively. The effects of
cromolyn on tumor growth in vivo were investigated in three
orthotopic
models (n = 20 mice per model) by administration of cromolyn (5 mg/kg
I'm sorry to hear of your mother's diagnosis.
If I were you, I'd leave the mice research to MD Anderson and the mice.
Best,
J
.
- References:
- Cromolyn and pancreatic cancer question.
- From: Phil
- Cromolyn and pancreatic cancer question.
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