New York Dermatology

Skin Cancer
http://www.newyorkdermatologygroup.org



Skin cancer occurs when skin cells start growing abnormally, causing
cancerous growths.

Most skin cancers develop on the visible outer layer of the skin (the
epidermis), particularly in sun-exposed areas (face, head, hands,
arms, and legs). They are usually easy to detect by examining the
skin, which increases the chances of early treatment and survival.
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What Types of Skin Cancer Are There?
There are different types of skin cancer, each named for the type of
skin cell from which they originated. The majority of skin cancers
fall into one of the following categories:

* Basal cell carcinoma (also called BCC) comes from the basal
cells in lowest part of the epidermis. 80-85% percent of skin cancers
are BCCs.
* Squamous cell carcinoma (also called SCC) comes from the skin
cells (keratinocytes) that make up the top layers of the skin. About
10% of skin cancers are SCC.
* Melanoma comes from skin cells called melanocytes, which create
pigment called melanin that gives skin its color. 5% of all skin
cancers are melanoma. Although less common, it is a very dangerous
type of skin cancer and is the leading cause of death from skin
disease.

Basal cell and squamous cell carcinoma are sometimes referred to as
“non-melanoma skin cancer” to distinguish them from melanoma.

Skin cancer is considered low risk when the affected cells remain
clustered in a single group. It is considered high risk when the cells
have invaded surrounding tissues. High risk forms of cancer require
more aggressive treatments.

Almost all skin cancers start as a small, low-risk lesions, but can
grow and become high-risk lesions if left untreated. Melanoma is the
most alarming type because it has a higher risk of invading
surrounding tissues or spreading to other parts of the body
(metastasis) before being detected. Squamous cell and basal cell skin
cancer are more likely to be detected and treated effectively before
they become malignant.

If skin cancer is detected before it has spread to surrounding
tissues, chances of a complete cure are excellent.

What Are Pre-Cancers?
Skin cancer may often be preceded by lesions called pre-cancers. The
most well-known of these are actinic keratoses (AKs). AKs are
considered an early form of squamous cell carcinoma.

AKs, a new or changing mole (nevi), and other unusual lesions on your
skin should be carefully monitored and brought to the attention of
your doctor.

How Is Skin Cancer Treated?
Diagnosing cancer usually requires a biopsy. A small piece of skin is
removed for examination under a microscope and evaluated with other
tests.

A treatment plan will be recommended based on several factors:

* The type of cancer
* The size of the cancer—treatments that may be effective for
small cancers may not be optimal for larger cancers
* The extent of the cancer (localized to one area vs. spreading to
surrounding tissues)
* The location of the cancer (face vs. arm)
* The number of lesions
* Your past history and family history of skin cancers

In general, the treatment plan is based on the risk of the cancer
spreading to another location or growing again (recurring) in the same
location. Cancers that are likely to spread or recur are treated more
aggressively.

Treatment options include:

Medications

* Aldara (imiquimod)
* 5-fluorouracil (Efudex, Carac)

Procedures

* Cryosurgery—A small amount of liquid nitrogen is used to
“freeze” away the lesion.
* Curettage-electrodessication—The tumor is scraped off using a
sharp-edged device called a curette. The surrounding skin is then
cauterized (heated) to prevent bleeding and further remove the tumor.
* Excision—The tumor is surgically removed along with a small
portion of surrounding skin. This usually requires stitches to control
bleeding and close the wound.
* Mohs surgery—A specialized surgery that removes the tumor in
stages. Each portion of removed tissue is examined under a microscope
to make sure that cancerous cells have been removed while sparing as
much normal skin as possible.

Radiation and chemotherapy may be recommended in cases when the cancer
has spread, or when other medical conditions prevent the use of other
treatments.

What Causes Skin Cancer?
Sunlight is composed of visible light (all the colors we see in
daylight), infrared radiation (which provides warmth), and ultraviolet
(UV) radiation, which is carcinogenic (cancer-causing). More than 90
percent of all skin cancer is caused by long-term exposure to UV
radiation.

UV radiation damages the skin’s DNA, causing a cell to behave
abnormally. The body normally has mechanisms to repair damaged DNA but
these repair mechanisms do not function normally after exposure to UV
radiation. This allows the abnormal skin cell to replicate itself,
making more cells with the same damaged DNA. This growing collection
of abnormal cells is the beginning of a cancer.

The immune system can often detect and destroy cancer cells, just as
it defends against infections by bacteria or viruses. However, UV
radiation disrupts the immune system so that our natural defenses may
not detect the cancer, allowing it to grow unchecked.

Melanin in the skin, which gives skin its tan to brown color, can
block the damaging effects of UV radiation. The more melanin, the
darker the skin. And the darker the skin, the better protected it is
from UV radiation. This is why a body darkens when exposed to sunlight
(tanning). It is trying to build a better shield.

However, the melanin provides only partial protection, even for those
with very dark skin. And those with fair skin have almost no melanin
to protect them.

It is important to remember that a tan develops only after the skin
has been damaged by UV radiation, and that this tan provides only
minor protection from additional damage.

In addition to sun exposure, family history may also play a role in a
small percentage of skin cancers, especially melanomas.

How Can I Prevent Skin Cancer?
The best protection against skin cancer is to minimize sun exposure,
especially between 10 a.m. and 4 p.m. If you do go out in the sun, use
a broad-spectrum sunscreen (SPF 30 or higher that protects against UVA
and UVB), making sure to cover the head, lips, hands, neck, and ears.
Wear a wide-brimmed hat, sunglasses, and protective clothing. Not only
will this dramatically decrease your risk of skin cancer, but it will
prevent other sun-damaging conditions, like wrinkles and actinic
keratoses.

While everyone should minimize their exposure to the sun, fair-skinned
people, outdoor workers, and residents of sunny climates should use
particular caution.

Another effective weapon against skin cancer is regular self-exams of
your skin. Get to know the landscape of your skin, and take an
inventory of all moles.

Because skin cancer can resemble other skin conditions, be sure to
tell your doctor about unusual skin changes or lesions, especially
these:

* A sore that comes and goes but never completely heals
* A shiny bump or nodule, especially if it appears pearly or
translucent (these can look brown or reddish and resemble a mole)
* A slightly raised pink growth with a crusted depression in the
center, possibly with tiny blood vessels (capillaries) visible on the
surface
* A patch of skin that is red or irritated, especially on the
chest, shoulders, or limbs
* A white or yellow-ish waxy scar with poorly defined borders

If you have any risk factors, such as prolonged sun exposure, family
history, or a past cancerous lesion, you may benefit from having your
skin checked regularly by your doctor.

Tanning booths increase the risk of developing skin cancer, despite
any claims of their being a safe alternative to natural sunlight. The
skin doesn’t tan unless it is first damaged by UV radiation.
Intentional tanning should be avoided like any health hazard, such as
smoking.

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This information is for general educational uses only. It may not
apply to you and your specific medical needs. This information should
not be used in place of a visit, call, consultation with or the advice
of your physician or health care professional. Communicate promptly
with your physician or other health care professional with any health-
related questions or concerns.

Be sure to follow specific instructions given to you by your physician
or health care professional.
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